Document Detail

Enhanced renal clearance of uric acid in hepatic cirrhosis.
MedLine Citation:
PMID:  7319788     Owner:  NLM     Status:  MEDLINE    
Serum and urinary acid were measured in 10 patients with chronic hepatitis, in 22 patients with hepatic cirrhosis, and in 11 control subjects. Significant differences were found in urinary acid excretion, uric acid clearance, and uric acid:creatinine clearance ratio between patients with hepatic cirrhosis and control subjects. Two patients with hepatic cirrhosis were found to have hypouricemia. They showed a two- to threefold increase in uric acid clearance and in the uric acid:creatinine clearance ratio compared with control subjects, but their 24-h uric acid excretion was normal. In patients with hepatic cirrhosis, a significant negative correlation was found between plasma testosterone level and either uric acid clearance or uric acid:creatinine clearance ratio. These results indicate that uric acid clearance may be increased in patients with hepatic cirrhosis and that hypouricemia may result from a change in renal handling of uric acid. Moreover, changes in plasma testosterone levels may play an important part in affecting the renal handling of uric acid in these patients.
T Higuchi; T Nakamura; H Uchino
Related Documents :
10517148 - A biomimetic phospholipid/alkanethiolate bilayer immobilizing uricase and an electron m...
12806038 - Wastewater minimization in indirect electrochemical synthesis of phenylacetaldehyde.
6633758 - Renal handling of uric acid in normal subjects by means of the pyrazinamide and probene...
9119628 - Biochemical relationship between urine composition and urinary stone formation in stone...
11181048 - Occurrence of d-amino acids and a pyridoxal 5'-phosphate-dependent aspartate racemase i...
1386328 - Presence and properties of acyl coenzyme a synthetase for medium-chain fatty acids in r...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Israel journal of medical sciences     Volume:  17     ISSN:  0021-2180     ISO Abbreviation:  Isr. J. Med. Sci.     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0013105     Medline TA:  Isr J Med Sci     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  1015-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Hepatitis / metabolism
Kidney / metabolism*
Liver / metabolism
Liver Cirrhosis / metabolism*
Middle Aged
Testosterone / blood
Uric Acid / metabolism*
Reg. No./Substance:
58-22-0/Testosterone; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Syndrome of inappropriate antidiuretic hormone secretion in newborn infants with respiratory problem...
Next Document:  Diagnostic characteristics of patients referred to a secondary care military medical facility of the...