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Enhanced renal Na+ reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men.
MedLine Citation:
PMID:  22874424     Owner:  NLM     Status:  Publisher    
We examined whether carbohydrate in beverages accelerated fluid retention during recovery from thermal and exercise-induced dehydration and whether it was caused in part by an enhanced renal Na(+) reabsorption rate due to insulin secretion. After dehydrating by ~2.3% body weight by exercise in a hot environment, seven young men underwent high carbohydrate, low carbohydrate, or control rehydration trials by drinking one of 3 beverages with 3.4g glucose + 3.1g fructose, 1.7g glucose + 1.6g fructose, or 0.0g glucose + 0.0g fructose per deciliter, respectively, in a common composition of electrolyte solution; 21meq•l(-1) [Na(+)], 5meq•l(-1) [K(+)], 16.5meq•l(-1) [Cl(-)], 10meq•l(-1) [citrate(3-)]. They drank the same amount of beverage as total body weight loss within 30min. During the 60min before the start of drinking and the following 180min, we measured plasma volume (PV), plasma glucose ([Glc](p)), serum insulin ([Ins](s)), plasma Na(+) concentrations, and the renal clearances of inulin, lithium, and Na+ with plasma vasopressin ([AVP](p)) and aldosterone concentrations ([Ald](p)) every 30min. After dehydration, PV decreased by ~5% and plasma osmolality increased by ~6mosmol•kgH(2)O(-1) in all trials with no significant differences among them. We found in the high carbohydrate trial that 1) PV increased faster than in the control trial and remained at the higher level than other trials for the last 60min (P<0.05), 2) accumulated urine volume was smallest after 90min (P<0.05), 3) the renal Na(+) reabsorption rate was greatest for the first 120min (P<0.05), 4) during which period [AVP](p) and [Ald](p) were not significantly different from other trials (both, P>0.9), and 5) [Glc](p) and [Ins]s were highest from 45 to 105min (P<0.05) during rehydration. Thus, carbohydrate in beverages enhances renal Na(+) reabsorption, and insulin is possibly involved in this enhancement.
Yoshi-Ichiro Kamijo; Shigeki Ikegawa; Yoshiyuki Okada; Shizue Masuki; Kazunobu Okazaki; Koji Uchida; Masao Sakurai; Hiroshi Nose
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-8
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Shinshu University Graduate School of Medicine.
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