| Enhanced ratio of linoleic acid to arachidonic acid in erythrocyte phosphatidylcholine in rats during withdrawal from ethanol. | |
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MedLine Citation:
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PMID: 7197409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Male Sprague-Dawley rats were pair-fed for 8 weeks either an alcohol diet or a control diet made isocaloric with dextrose. Those on the alcohol diet were then fed the control diet for 3 days and both groups were killed. Analysis of the fatty acid composition of the various blood lipids showed that the relative level of 18:2 to 20:4 was significantly greater in the phosphatidylcholine fraction from erythrocytes of rats withdrawn from alcohol as compared to that from control animals. It has been suggested that in alcohol-fed animals the hepatic capacity to produce 20:4 from 18:2 is reduced. Therefore the increase in the ratio of 18:2/20:4 in erythrocyte phosphatidylcholine could serve as an index to detect the liver malfunction and to confirm recent chronic alcohol consumption. |
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Authors:
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G A Rao; S C Goheen; M Manix; E C Larkin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Toxicology letters Volume: 7 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1980 Nov |
Date Detail:
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Created Date: 1981-12-21 Completed Date: 1981-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 37-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acids / blood* Erythrocytes / analysis* Ethanol / adverse effects* Humans Linoleic Acids / blood* Phosphatidylcholines / blood* Rats Rats, Inbred Strains Substance Withdrawal Syndrome / blood* |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Linoleic Acids; 0/Phosphatidylcholines; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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