| Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failure by non-linear analysis: oxygen uptake efficiency slope. | |
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MedLine Citation:
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PMID: 16338939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Predicting survival from peak exercise oxygen uptake (peak VO2) in chronic heart failure (CHF) is hindered by its reduction if exercise duration is submaximal. The oxygen uptake efficiency slope (OUES) is a non-linear description of the ventilatory response to exercise, which has the potential to describe abnormalities even early in exercise. We evaluated the physiology of OUES and assessed its potential for prognostic information in patients with CHF. METHODS AND RESULTS: Two hundred and forty-three patients with CHF (mean age 59+/-12 years) underwent cardiopulmonary exercise testing between May 1992 and July 1996. Mean peak VO2 was 16.2+/-6.7 mL/kg/min, VE/VCO2 slope 38+/-12.5, ventilatory anaerobic threshold 10.9+/-3.5 mL/kg/min, and OUES 1.6+/-0.7 L/min. The value for each variable fell across the New York Heart Association classes (P<0.0001 by analysis of variance for each). When only the first 50% of each exercise test was used to calculate the variables, the value obtained for OUES changed the least (peak VO2 25% difference and OUES 1% difference). After a median of 9 years of follow-up, 139 patients (57%) had died. Each of the exercise variables was a significant univariate predictor of prognosis but in a multivariable model, only OUES was identified as the sole significant independent prognostic variable. CONCLUSION: OUES provides an effective, independent measure of pathological exercise physiology. Its numerical value is relatively insensitive to the duration of exercise data from which it is calculated. Its prognostic value seems to be stronger than the best available existing measures of exercise physiology. |
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Authors:
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Lewis Ceri Davies; Roland Wensel; Panagiota Georgiadou; Mariantonietta Cicoira; Andrew J S Coats; Massimo F Piepoli; Darrel P Francis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-12-07 |
Journal Detail:
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Title: European heart journal Volume: 27 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-03 Completed Date: 2006-05-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 684-90 Citation Subset: IM |
Affiliation:
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National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK. lewisceridavies@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Exercise / physiology* Exercise Test / methods Female Heart Failure / physiopathology* Humans Male Middle Aged Oxygen Consumption / physiology* Predictive Value of Tests Prognosis Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2006 Oct;27(20):2483
[PMID:
17000633
]
Eur Heart J. 2006 Mar;27(6):633-4 [PMID: 16401676 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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