| Enhanced production of oxygen radicals in asthma. | |
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MedLine Citation:
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PMID: 8288953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxygen radicals have been implicated in a variety of disease processes including asthma. In this study we investigated the production of superoxide by airspace cells in 56 patients with asthma as compared with 49 normal controls. We found that with patients with asthma with a forced expiratory vital capacity in the 1st second (FEV1) of less than 80% (n = 13) had higher spontaneous superoxide (SO) production when compared with normal subjects (3.6 +/- 1.0 versus 1.9 +/- 0.2 nmol/5 x 10(5) cells/hour, p < 0.01), whereas those with FEV1 > 80% (n = 40) were similar to normal subjects in superoxide generation (2.1 +/- 0.3 nmol/5 x 10(5) cells/hour). Airspace cells from patients with mild asthma and those with moderate asthma had higher phorbol myristate acetate (PMA)-stimulated SO production when compared with those from normal subjects (8.9 +/- 0.7, 11.1 +/- 2.4, and 6.5 +/- 0.4 nmol/5 x 10(5) cells/hour respectively, p < 0.005, r = -0.35, both comparisons). However, PMA-stimulated SO production was similar in both asthmatic subgroups. Finally, spontaneous generation of SO inversely correlated with FEV1% prediction (r = 0.35, p < 0.01) in the asthma group. We conclude that worsening of airway obstruction in asthma is associated with increased spontaneous generation of SO by airspace leukocytes. |
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Authors:
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N N Jarjour; W J Calhoun |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of laboratory and clinical medicine Volume: 123 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-02-18 Completed Date: 1994-02-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 131-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Wisconsin Medical School, Madison. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Asthma / metabolism*, pathology, physiopathology Bronchoalveolar Lavage Fluid / chemistry Bronchoscopy Forced Expiratory Volume Humans Middle Aged Reactive Oxygen Species / metabolism* Respiratory System / metabolism*, pathology, physiopathology Superoxides / metabolism Vital Capacity |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; 11062-77-4/Superoxides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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