Document Detail

Enhanced platelet aggregability under high shear stress after treadmill exercise in patients with effort angina.
MedLine Citation:
PMID:  8725732     Owner:  NLM     Status:  MEDLINE    
Platelet activation induced by shear forces occurring in a stenosed coronary artery is one of the mechanisms of coronary thrombosis. We evaluated the shear-induced platelet aggregation (SIPA) dynamics in patients with effort angina during treadmill exercise. SIPA was measured by a rotational cone-plate aggregometer. SIPA was markedly increased by exercise from 71.2 +/- 8.9% to 81.9 +/- 7.6% (p < 0.01) in the patient group. Although epinephrine concentrations were elevated, its rate of increase was not correlated with that of SIPA. Yohimbine partially inhibited the exercise-induced increase in SIPA. In contrast, a significant correlation between the changing rate of plasma von Willebrand factor (vWF) larger multimers and that of SIPA (r = 0.74, p < 0.05) was observed. Exercise-augmented SIPA is probably dependent on an increase in vWF larger multimers rather than platelet alpha2-receptor activation. Prevention of the interaction between vWF and its platelet receptors may play some role in decreasing the risk of coronary thrombosis during exercise.
J Tokuue; J Hayashi; Y Hata; K Nakahara; Y Ikeda
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  75     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-01-21     Completed Date:  1997-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  833-7     Citation Subset:  IM    
Department of Medicine and Gerontology, Kyorin University, Tokyo, Japan.
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MeSH Terms
Angina Pectoris / blood*
Epinephrine / blood*
Exercise Test
Middle Aged
Platelet Aggregation*
Stress, Mechanical
Reg. No./Substance:

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