| Enhanced plasma soluble CD40 ligand levels in essential hypertensive patients with blunted nocturnal blood pressure decrease. | |
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MedLine Citation:
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PMID: 17198914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hypertensives with a blunted nocturnal blood pressure (BP) decrease have increased risk of developing atherosclerotic disease. Soluble CD40 ligand (sCD40L) is involved in the pathogenesis of risk factor-related vascular damage. Therefore, we evaluated the relationship between circulating sCD40L levels, circadian BP profile, and early carotid atherosclerosis in essential hypertensives. METHODS: Plasma sCD40L concentrations were assessed in two groups of 25 never-treated hypertensives, without additional cardiovascular risk factors, differentiated on the basis of a nocturnal decrease of BP either of >10% (dippers) or <10% (nondippers) of daytime values, and in 25 matched normotensives. Carotid intima-media thickness (IMT) was also measured in all participants. RESULTS: Plasma sCD40L concentrations were higher in nondippers (4.9 +/- 1.2 ng/mL) than in dippers (3.7 +/- 0.7, P = .0005) and controls (1.6 +/- 0.6, P < .0001). These latter had lower sCD40L concentrations than dippers (P < .0001). The IMT was higher in both hypertensive groups than in normotensives (P < .0001). In the entire hypertensive population IMT directly correlated with circulating levels of sCD40L (r = 0.365, P = .01) and inversely correlated with nocturnal systolic BP decreases (r = -0.286, P = .043). In a multivariate regression analysis sCD40L was the main determinant of IMT (r(2) = 0.157, P = .004). CONCLUSIONS: Nondippers have enhanced plasma sCD40L levels, which may contribute to their increased susceptibility to develop vascular damage. |
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Authors:
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Giovambattista Desideri; Francesco Cipollone; Letizia Valeri; Davide Grassi; Stefano Necozione; Giuseppe Croce; Gabriella Passacquale; Angela Garofalo; Cristina Lippi; Andrea Mezzetti; Claudio Ferri |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hypertension Volume: 20 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-02 Completed Date: 2007-03-15 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 70-6; discussion 77 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Public Health, University of L'Aquila, Piazzale Salvatore Tommasi 1, 67100 Coppito, L'Aquila, Italy. giovambattista.desideri@cc.univaq.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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physiology* C-Reactive Protein / metabolism CD40 Ligand / blood* Carotid Artery, Common / pathology Circadian Rhythm / physiology* Humans Hypertension / blood, pathology, physiopathology* Isoprostanes / blood Middle Aged Platelet Activation / physiology |
| Chemical | |
Reg. No./Substance:
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0/Isoprostanes; 147205-72-9/CD40 Ligand; 9007-41-4/C-Reactive Protein |
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