Document Detail


Enhanced photostability of ICG in close proximity to gold colloids.
MedLine Citation:
PMID:  12963458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Photobleaching of fluorophores frequently limits their detectability or observation time. We examined Indocyanine green (ICG) which is widely used in medical testing and is highly unstable. We showed that spatial localization of ICG near metallic gold colloids resulted in increased photostability. This suggests the use of fluorophore-metal conjugates in situations adversely affected by photobleaching.
Authors:
Chris D Geddes; Haishi Cao; Joseph R Lakowicz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy     Volume:  59     ISSN:  1386-1425     ISO Abbreviation:  Spectrochim Acta A Mol Biomol Spectrosc     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-09     Completed Date:  2004-06-03     Revised Date:  2011-05-04    
Medline Journal Info:
Nlm Unique ID:  9602533     Medline TA:  Spectrochim Acta A Mol Biomol Spectrosc     Country:  England    
Other Details:
Languages:  eng     Pagination:  2611-7     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Center for Fluorescence Spectroscopy, 725 West Lombard Street, Baltimore, MD 21201, USA. chris@cfs.umbi.umd.edu
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MeSH Terms
Descriptor/Qualifier:
Gold Colloid / chemistry,  metabolism*
Indocyanine Green / chemistry,  metabolism*,  radiation effects
Light*
Spectrophotometry
Time Factors
Grant Support
ID/Acronym/Agency:
EB-00682/EB/NIBIB NIH HHS; P41 RR008119-13/RR/NCRR NIH HHS; P41 RR008119-14/RR/NCRR NIH HHS; R01 EB000682-04/EB/NIBIB NIH HHS; R01 EB000682-05/EB/NIBIB NIH HHS; RR-08119/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Gold Colloid; 3599-32-4/Indocyanine Green
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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