Document Detail

Enhanced oxygen metabolism of peritoneal macrophages in the presence of murine neuroblastoma cells is partly caused by enkephalins.
MedLine Citation:
PMID:  3170721     Owner:  NLM     Status:  MEDLINE    
A bioluminescent technique was used to show that murine neuroblastoma (NB) cells or cell-free extracts (H variant) were able to enhance the release of reactive oxygen intermediates (ROI) from peritoneal macrophages in vitro. L-variant NB cells were ineffective. Physiological concentrations of met-enkephalin produced the same effect in vitro but not leu-enkephalin. When both H- and L-variant cells, or their extracts, were incubated together with macrophages, ROI production was not increased. Similar findings were detectable when met- and leu-enkephalin were cultured together with macrophages. In vivo, preliminary studies gave the same results. The concentration rate of met- to leu-enkephalin was higher in H-variant than in L-variant NB cells. We conclude from our results that met-enkephalin can enhance the release of ROI from peritoneal macrophages. The difference in the effects produced by the H and L variants is due to differences in the concentrations of enkephalins released.
J Willems; G Leclercq; M Joniau
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  19     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-11-04     Completed Date:  1988-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  269-78     Citation Subset:  IM    
Interdisciplinary Research Center, K.U. Leuven, Kortrijk, Belgium.
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MeSH Terms
Antigenic Variation
Enkephalins / physiology*
Macrophages / metabolism*
Mice, Inbred Strains
Neuroblastoma / analysis,  immunology,  pathology*
Oxygen Consumption* / drug effects
Peritoneal Cavity / cytology*
Tissue Extracts / pharmacology
Tumor Cells, Cultured
Reg. No./Substance:
0/Enkephalins; 0/Tissue Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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