Document Detail

Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging.
MedLine Citation:
PMID:  22734778     Owner:  NLM     Status:  In-Data-Review    
The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 μm depth and 31% enhancement in image depth Z(threshold).
Xiang Wen; Steven L Jacques; Valery V Tuchin; Dan Zhu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  17     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  066022     Citation Subset:  IM    
Huazhong University of Science and Technology, Britton Chance Center for Biomedical Photonics, Wuha National Laboratory for Optoelectronics, Wuhan 430074, China.
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