Document Detail

Enhanced norepinephrine release in hypothalamus from locus coeruleus in SHR.
MedLine Citation:
PMID:  1676763     Owner:  NLM     Status:  MEDLINE    
The hypothesis that a functional projection from the locus coeruleus (LC) to the posterior hypothalamus contributes to the development of hypertension in SHR, was tested by measuring norepinephrine (NE) in the posterior hypothalamus by brain dialysis after injections of L-glutamate (L-glu) into LC. L-glu elicited a prolonged elevation of blood pressure in both SHR and WKY. Pressor effects were significantly larger in SHR than in WKY. Extracellular NE in the posterior hypothalamus increased after LC stimulation; NE release was significantly higher in SHR than in WKY. Injections of 6-hydroxydopamine (6-OHDA) into posterior hypothalamus lowered the resting blood pressure and attenuated the pressor responses to L-glu injections into the LC in SHR. These findings suggest that the LC projects functionally to the posterior hypothalamus and that the projection can contribute to the development of hypertension in SHR.
S Kawasaki; K Takeda; M Tanaka; H Itoh; M Hirata; T Nakata; J Hayashi; M Oguro; S Sasaki; M Nakagawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  32     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-08-15     Completed Date:  1991-08-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  255-62     Citation Subset:  IM    
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
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MeSH Terms
Blood Pressure / drug effects
Glutamates / administration & dosage,  pharmacology
Glutamic Acid
Hydroxydopamines / administration & dosage,  pharmacology
Hypertension / etiology*
Hypothalamus / metabolism*,  physiology
Locus Coeruleus / metabolism*,  physiology
Norepinephrine / metabolism*
Rats, Inbred SHR
Rats, Inbred WKY
Reg. No./Substance:
0/Glutamates; 0/Hydroxydopamines; 1199-18-4/Oxidopamine; 51-41-2/Norepinephrine; 56-86-0/Glutamic Acid

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