Document Detail


Enhanced neural drive after maximal strength training in multiple sclerosis patients.
MedLine Citation:
PMID:  20512584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple sclerosis (MS) patients suffer from impaired muscle activation and lower limb strength. Strength training enhances muscle activation and muscle strength, but neural adaptations to strength training remain unexplored in MS patients. The hypothesis was that maximal strength training (MST) using high loads and few repetitions would improve central neural drive and thus strength capacity of MS patients. 14 MS patients staying at a national MS rehabilitation center were randomly assigned to a MST group or a control group (CG). Both groups received "today's treatment". In addition, the MST group trained 4 x 4 repetitions of unilateral dynamic leg press and plantar flexion 5 days a week for 3 weeks. Neural adaptations of the soleus muscle were assessed by surface electromyography (EMG) activity, and by superimposed H-reflexes and V-waves obtained during maximum voluntary isometric plantar flexor contractions (MVCs). H-reflexes and V-waves were normalized by the M-wave (H(SUP)/M(SUP), V/M(SUP), respectively). In the MST group, MVC increased by 20 +/- 9% (P < 0.05). Soleus EMG activity and V/M(SUP) ratio increased by 40 and 55%, respectively, in the MST group compared to the CG (P <or= 0.05). The H(SUP)/M(SUP) ratio remained unchanged. No change was apparent in the CG. MST group subjects were able to complete all training sessions. No adverse effects were reported. This randomized study provides evidence that MST is effective of augmenting the magnitude of efferent motor output of spinal motor neurons in MS patients, alleviating some neuromuscular symptoms linked to the disease.
Authors:
Marius S Fimland; Jan Helgerud; Markus Gruber; Gunnar Leivseth; Jan Hoff
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-05-30
Journal Detail:
Title:  European journal of applied physiology     Volume:  110     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  435-43     Citation Subset:  IM    
Affiliation:
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. marius.steiro.fimland@stolav.no
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Adult
Aged
Electromyography
Evoked Potentials, Motor
Female
H-Reflex
Humans
Isometric Contraction*
Lower Extremity
Male
Middle Aged
Motor Neurons*
Multiple Sclerosis / physiopathology,  therapy*
Muscle Strength*
Muscle, Skeletal / innervation*
Resistance Training*
Time Factors
Torque
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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