Document Detail

Enhanced neophobia but normal plasma corticosterone levels in rats with dorsal noradrenergic bundle lesions.
MedLine Citation:
PMID:  6817347     Owner:  NLM     Status:  MEDLINE    
The effects of dorsal noradrenergic bundle (DNB) lesions on plasma corticosterone levels were determined in male albino rats. DNB lesions did not affect baseline plasma corticosterone levels. Furthermore, the increased corticosterone levels produced by various environmental manipulations did not differ between control and DNB lesioned groups. However, the lesioned group did exhibit longer latencies to eat familiar food in novel environments, as well as to eat novel foods in a familiar environment. Latencies to eat novel food in novel environments did not differ between the two groups and this was attributed to a "ceiling" effect. These endocrinological data fail to support the hypothesis that the enhanced "neophobia" observed in DNB lesioned rats is due to an increase in the intensity of the emotional reaction to novel stimuli. The data do not preclude the possibility, however, that the enhanced neophobic reactions reflect impaired habituation to these stimuli.
M T Martin-Iverson; M Pisa; E Chan; H C Fibiger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  17     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-02-25     Completed Date:  1983-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  639-43     Citation Subset:  IM    
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MeSH Terms
Brain / drug effects,  physiology*
Corpus Striatum / metabolism
Corticosterone / blood*
Dopamine / metabolism
Feeding Behavior* / drug effects
Habituation, Psychophysiologic
Hippocampus / metabolism
Hydroxydopamines / pharmacology*
Hypothalamus / metabolism
Norepinephrine / metabolism*
Reg. No./Substance:
0/Hydroxydopamines; 1199-18-4/Oxidopamine; 50-22-6/Corticosterone; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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