| Enhanced myocardial protection with adenosine. | |
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MedLine Citation:
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PMID: 2757434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was undertaken to investigate whether adenosine administered during cardioplegic arrest could enhance myocardial protection and improve recovery of function after ischemia. Isolated perfused rabbit hearts were subjected to 120 minutes of hypothermic (32 degrees C) multidose cardioplegia-induced ischemia. Control hearts (n = 23) received modified St. Thomas's cardioplegia, and the remaining hearts received cardioplegia with either 100 microM (n = 11), 200 microM (n = 11), or 400 microM (n = 11) adenosine. After ischemia and 45 minutes of reperfusion, left ventricular contractility was superior in all groups of adenosine-treated hearts compared with control hearts. Furthermore, there was a significant incremental increase in functional recovery with increasing dose of adenosine. Postischemic diastolic stiffness was significantly better in all adenosine groups compared with controls. No differences were noted in coronary flow or myocardial water content between adenosinetreated and control hearts. These data demonstrate that adenosine administered in these concentrations provides myocardial protection and improved recovery of both systolic and diastolic function after global ischemia, presumably metabolically by reducing depletion of adenosine triphosphate or enhancing repletion of adenosine triphosphate and enabling improved postischemic recovery. |
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Authors:
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S F Bolling; L E Bies; K P Gallagher; E L Bove |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 47 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-09-01 Completed Date: 1989-09-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 809-15 Citation Subset: AIM; IM |
Affiliation:
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Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor 48109. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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therapeutic use* Adenosine Triphosphate / metabolism Animals Bicarbonates Calcium Chloride Cardioplegic Solutions / therapeutic use* Heart Arrest, Induced Magnesium Male Myocardial Contraction / drug effects Myocardial Reperfusion Injury / prevention & control* Myocardium / metabolism Potassium Chloride Rabbits Sodium Chloride |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 0/Cardioplegic Solutions; 0/St. Thomas' Hospital cardioplegic solution; 10043-52-4/Calcium Chloride; 56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine; 7439-95-4/Magnesium; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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