Document Detail


Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (CD36 deficiency).
MedLine Citation:
PMID:  10025829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD36 is a multifunctional, 88 kDa glycoprotein that is expressed on platelets and monocytes/macrophages. CD36 also has high homology with the long-chain fatty acid (LFA) transporter in the myocardium. Although platelet and monocyte CD36 levels can indicate a CD36 deficiency, they cannot predict specific clinical manifestations in the myocardium of a given person. We examined the hypothesis that a deficiency in LFA transport augments myocardial glucose uptake in patients with a type I CD36 deficiency. METHODS: Seven fasting patients with a type I CD36 deficiency and 9 controls were assessed by cardiac radionuclide imaging using beta-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) as a LFA tracer and by PET with 18F-fluorodeoxyglucose (FDG). RESULTS: None of the patients with a CD36 deficiency showed myocardial uptake of BMIPP. The percentage dose uptake of BMIPP in these subjects was significantly lower than that in normal controls (1.31+/-0.24 versus 2.90+/-0.2; P < 0.005). PET studies revealed that myocardial FDG accumulation was substantially increased in patients with a CD36 deficiency. Quantitative analysis showed that the percentage dose uptake of FDG in patients with a CD36 deficiency was significantly higher than that in normal controls (1.28+/-0.35 versus 0.43+/-0.22; P< 0.01). CONCLUSION: CD36 functions as a major myocardial LFA transporter and its absence may cause a compensatory upregulation of myocardial glucose uptake.
Authors:
K Fukuchi; S Nozaki; T Yoshizumi; S Hasegawa; T Uehara; T Nakagawa; T Kobayashi; Y Tomiyama; S Yamashita; Y Matsuzawa; T Nishimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  40     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-03-05     Completed Date:  1999-03-05     Revised Date:  2006-05-06    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
Affiliation:
Division of Tracer Kinetics, Biomedical Research Center, Osaka University Medical School, Suita, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antigens, CD36 / metabolism,  physiology*
Blood Platelets / immunology
Carrier Proteins / metabolism*
Fatty Acids / diagnostic use,  metabolism*
Female
Flow Cytometry
Fluorodeoxyglucose F18 / diagnostic use
Glucose / metabolism*
Heart / radionuclide imaging
Heart Diseases / metabolism,  radionuclide imaging
Humans
Iodobenzenes / diagnostic use
Male
Middle Aged
Monocytes / immunology
Myocardium / metabolism*
Radiopharmaceuticals / diagnostic use
Thallium / diagnostic use
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon
Chemical
Reg. No./Substance:
0/Antigens, CD36; 0/Carrier Proteins; 0/Fatty Acids; 0/Iodobenzenes; 0/Radiopharmaceuticals; 116754-87-1/iodofiltic acid; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18; 7440-28-0/Thallium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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