Document Detail

Enhanced myocardial contractility associated with hypercalcaemia of hyperparathyroidism - a case study in six patients.
MedLine Citation:
PMID:  12844199     Owner:  NLM     Status:  MEDLINE    
The possible association of increased left ventricular ejection fraction (LVEF) in patients with increased serum Ca(2+) was observed in our clinic. Six patients with confirmed primary hyperparathyroidism and hypercalcaemia were studied prospectively. Tc-99m sestamibi gated SPECT was done pre- and postoperatively. The LVEF was abnormally high in all the patients pre-operatively, i.e. above the normal reference range (47-61%) as used in our clinic. It decreased in all of them postoperatively, yet in only three patients to values within the normal range. This was associated with normalisation of the serum Ca(2+) values. The median of the pre-operative LVEF was 74% and postoperative it was 61.5%. The median difference was 9% with a 95% CI for the median difference for paired data (6; 26). This was statistically significant. Increased LVEF was not previously described as part of the clinical picture of primary hyperparathyroidism. The in vivo effect of chronic hypercalcaemia on LV pump function my need to be revisited.
Anton C Otto; Maria G Nel; Johan A Van Staden; Marianna Dunn; Andries Van Aswegen; Riette Nel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners     Volume:  14     ISSN:  -     ISO Abbreviation:  Cardiovasc J S Afr     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-07-04     Completed Date:  2003-10-23     Revised Date:  2014-01-13    
Medline Journal Info:
Nlm Unique ID:  100964061     Medline TA:  Cardiovasc J S Afr     Country:  South Africa    
Other Details:
Languages:  eng     Pagination:  141-3     Citation Subset:  IM    
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MeSH Terms
Confidence Intervals
Follow-Up Studies
Hypercalcemia / complications,  diagnosis*
Hyperparathyroidism / complications,  diagnosis*,  surgery*
Myocardial Contraction / physiology
Postoperative Care
Preoperative Care
Prospective Studies
Risk Assessment
Sampling Studies
Stroke Volume*
Technetium Tc 99m Sestamibi / diagnostic use
Thyroidectomy / methods
Tomography, Emission-Computed, Single-Photon
Ventricular Dysfunction, Left / complications,  radionuclide imaging*
Reg. No./Substance:
971Z4W1S09/Technetium Tc 99m Sestamibi

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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