Document Detail

Enhanced metabolic response to caffeine in exercise-trained human subjects.
MedLine Citation:
PMID:  3902769     Owner:  NLM     Status:  MEDLINE    
The effect of caffeine on resting metabolic rate (RMR) was investigated in eight trained and eight nontrained young male subjects. The ingestion of 4 mg/kg caffeine produced a greater increase of RMR in trained subjects. This effect was associated with a greater increase in plasma free fatty acids and a larger fall in respiratory quotient, indicating an enhanced lipid oxidation following caffeine in exercise-trained subjects. An initial fall in plasma glucose was observed but only in trained subjects, and caffeine did not change plasma insulin in either group studied. Caffeine caused a significant fall in plasma norepinephrine and an increase in plasma epinephrine in both groups of subjects, but this action was significantly greater in trained subjects. It is suggested that the greater increase in RMR observed in trained subjects following caffeine ingestion is related to an enhanced lipid mobilization, possibly produced by a greater epinephrine secretion and by subsequent increased lipid oxidation.
J LeBlanc; M Jobin; J Côté; P Samson; A Labrie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  59     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-12-10     Completed Date:  1985-12-10     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  832-7     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / metabolism
Blood Glucose / metabolism
Body Weight
Caffeine / pharmacology*
Epinephrine / blood
Fatty Acids, Nonesterified / metabolism
Heart Rate / drug effects
Insulin / blood
Lipid Mobilization / drug effects*
Oxygen Consumption / drug effects
Physical Exertion*
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Insulin; 51-43-4/Epinephrine; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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