| Enhanced mRNA expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in breast carcinomas is correlated with adverse prognosis. | |
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MedLine Citation:
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PMID: 12115876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tissue inhibitor of metalloproteinase-1 (TIMP-1) has emerged as a multifunctional protein with the contrasting activities of inhibiting tissue-degrading enzymes and promoting cellular growth. In an attempt to elucidate the clinical significance of TIMP-1 in breast cancer, the expression of TIMP-1 mRNA was evaluated in 117 invasive breast carcinomas by mRNA in situ hybridization, in correlation with clinicopathological parameters, immunohistochemical prognostic factors (Ki-67, c-erb-B-2, bcl-2) and clinical outcome. TIMP-1 was detected in stromal cells in areas within the tumours and at the tumour margin. High TIMP-1 mRNA expression in the marginal portion of the tumours was significantly correlated with lymph node metastasis (p<0.05) and c-erbB-2 expression (p<0.05). On the other hand, increased TIMP-1 mRNA expression within the tumours showed a statistically significant correlation with ER detection (p<0.01). Multivariate analysis revealed worse survival for patients with high TIMP-1 mRNA expression in the marginal portion of the tumours; the subgroup of these patients co-expressing high levels of TIMP-1 mRNA within the tumours as well had even worse survival (p=0.042). In conclusion, our data support the multifunctional role of TIMP-1, particularly its growth-promoting activity, on the basis of its significant correlation with lymph node metastasis and adverse prognosis. In addition to the latter property, a probable association of TIMP-1 with tumour cell differentiation is suggested by its topographical correlation with ER detection. |
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Authors:
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Lydia Nakopoulou; Ioanna Giannopoulou; Kalliopi Stefanaki; Effie Panayotopoulou; Ioanna Tsirmpa; Paraskevi Alexandrou; John Mavrommatis; Sophia Katsarou; Panagiotis Davaris |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pathology Volume: 197 ISSN: 0022-3417 ISO Abbreviation: J. Pathol. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-12 Completed Date: 2002-09-09 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: England |
Other Details:
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Languages: eng Pagination: 307-13 Citation Subset: IM |
Copyright Information:
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Copyright 2002 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Pathology, Athens National University Medical School, Greece. lnakopou@cc.uoa.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Biological Markers / analysis Breast Neoplasms / metabolism*, mortality Carcinoma, Ductal, Breast / metabolism*, mortality Carcinoma, Lobular / metabolism*, mortality Chi-Square Distribution Female Humans Immunohistochemistry / methods In Situ Hybridization / methods Ki-67 Antigen / analysis Lymphatic Metastasis Middle Aged Proto-Oncogene Proteins c-bcl-2 / analysis RNA, Messenger / metabolism* Receptor, erbB-2 / analysis Ribonuclease, Pancreatic / diagnostic use Survival Rate Tissue Inhibitor of Metalloproteinase-1 / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Ki-67 Antigen; 0/Proto-Oncogene Proteins c-bcl-2; 0/RNA, Messenger; 0/Tissue Inhibitor of Metalloproteinase-1; EC 2.7.10.1/Receptor, erbB-2; EC 3.1.27.5/Ribonuclease, Pancreatic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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