Document Detail


Enhanced mRNA expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in breast carcinomas is correlated with adverse prognosis.
MedLine Citation:
PMID:  12115876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tissue inhibitor of metalloproteinase-1 (TIMP-1) has emerged as a multifunctional protein with the contrasting activities of inhibiting tissue-degrading enzymes and promoting cellular growth. In an attempt to elucidate the clinical significance of TIMP-1 in breast cancer, the expression of TIMP-1 mRNA was evaluated in 117 invasive breast carcinomas by mRNA in situ hybridization, in correlation with clinicopathological parameters, immunohistochemical prognostic factors (Ki-67, c-erb-B-2, bcl-2) and clinical outcome. TIMP-1 was detected in stromal cells in areas within the tumours and at the tumour margin. High TIMP-1 mRNA expression in the marginal portion of the tumours was significantly correlated with lymph node metastasis (p<0.05) and c-erbB-2 expression (p<0.05). On the other hand, increased TIMP-1 mRNA expression within the tumours showed a statistically significant correlation with ER detection (p<0.01). Multivariate analysis revealed worse survival for patients with high TIMP-1 mRNA expression in the marginal portion of the tumours; the subgroup of these patients co-expressing high levels of TIMP-1 mRNA within the tumours as well had even worse survival (p=0.042). In conclusion, our data support the multifunctional role of TIMP-1, particularly its growth-promoting activity, on the basis of its significant correlation with lymph node metastasis and adverse prognosis. In addition to the latter property, a probable association of TIMP-1 with tumour cell differentiation is suggested by its topographical correlation with ER detection.
Authors:
Lydia Nakopoulou; Ioanna Giannopoulou; Kalliopi Stefanaki; Effie Panayotopoulou; Ioanna Tsirmpa; Paraskevi Alexandrou; John Mavrommatis; Sophia Katsarou; Panagiotis Davaris
Related Documents :
17728286 - Matrix metalloproteinase-13 is required for zebra fish (danio rerio) development and is...
16732316 - Radiation-enhanced hepatocellular carcinoma cell invasion with mmp-9 expression through...
1928226 - The role of the matrix metalloproteinase stromelysin in the progression of squamous cel...
19617536 - Gliomas induce and exploit microglial mt1-mmp expression for tumor expansion.
18523266 - Proteasome inhibitors enhance trail-induced apoptosis through the intronic regulation o...
20126666 - Correction: cx(3)cr1 is expressed by human b lymphocytes and mediates cx(3)cl1 driven c...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pathology     Volume:  197     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-12     Completed Date:  2002-09-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-13     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Ltd.
Affiliation:
Department of Pathology, Athens National University Medical School, Greece. lnakopou@cc.uoa.gr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biological Markers / analysis
Breast Neoplasms / metabolism*,  mortality
Carcinoma, Ductal, Breast / metabolism*,  mortality
Carcinoma, Lobular / metabolism*,  mortality
Chi-Square Distribution
Female
Humans
Immunohistochemistry / methods
In Situ Hybridization / methods
Ki-67 Antigen / analysis
Lymphatic Metastasis
Middle Aged
Proto-Oncogene Proteins c-bcl-2 / analysis
RNA, Messenger / metabolism*
Receptor, erbB-2 / analysis
Ribonuclease, Pancreatic / diagnostic use
Survival Rate
Tissue Inhibitor of Metalloproteinase-1 / genetics*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Ki-67 Antigen; 0/Proto-Oncogene Proteins c-bcl-2; 0/RNA, Messenger; 0/Tissue Inhibitor of Metalloproteinase-1; EC 2.7.10.1/Receptor, erbB-2; EC 3.1.27.5/Ribonuclease, Pancreatic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Loss of heterozygosity in the clonal evolution of flat colorectal neoplasms.
Next Document:  Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to...