Document Detail

Enhanced lung maturation in cocaine-exposed rabbit fetuses.
MedLine Citation:
PMID:  1866207     Owner:  NLM     Status:  MEDLINE    
Because of cocaine's possible effect on the incidence of respiratory distress syndrome in offspring of cocaine-addicted mothers, we have studied the effects of maternal exposure to cocaine on the functional anatomy of fetal rabbit lungs. Pregnant dams were injected s.c. daily with either cocaine (18 mg/kg) or an equal volume of 0.9% NaCl at 24, 25, and 26 d gestation. Cocaine metabolites were confirmed both in urine of treated dams and in fetal amniotic fluid. Serum cortisol levels were higher in treated dams than in controls. Fetuses were delivered through hysterotomy at 27 d. Tracheas were cannulated and a volume-pressure diagram was obtained during initial lung inflation-deflation. Volume was measured for 2 min at each pressure (P) increment of 5 cm H2O. Body weights and dry lung weights were comparable between the two groups. In contrast, cocaine-exposed lungs differed from controls as follows: 1) wet lung weights were lower (0.79 versus 0.89 g, p less than 0.02); 2) opening pressure was lower (P25 versus P35); 3) volume (mL/kg) was higher in treated animals at each pressure step (p less than 0.05); 4) end-deflation volume at P0 was higher (30.4 versus 0.8 mL/kg, p less than 0.001); and 5) bubbles released from saccules by micropuncture, which were stable by Pattle's criteria, had estimated surface tension near zero (controls produced no stable bubbles). Light micrographs of cocaine-exposed fetuses revealed more secondary septa and thinner septal walls than controls.(ABSTRACT TRUNCATED AT 250 WORDS)
Z N Kain; M R Chinoy; M T Antonio-Santiago; R N Marchitelli; E M Scarpelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  29     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-09-06     Completed Date:  1991-09-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  534-7     Citation Subset:  IM    
Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York 11042.
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MeSH Terms
Catecholamines / physiology
Cocaine / toxicity*
Fetal Organ Maturity / drug effects
Gestational Age
Glucocorticoids / physiology
Lung / drug effects*,  embryology,  pathology
Maternal-Fetal Exchange
Substance-Related Disorders / pathology
Reg. No./Substance:
0/Catecholamines; 0/Glucocorticoids; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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