Document Detail

Enhanced lipid peroxidation in patients during coronary artery bypass grafting.
MedLine Citation:
PMID:  8070827     Owner:  NLM     Status:  MEDLINE    
Lipid peroxidation products were measured at various time intervals in 20 patients with coronary artery disease, who underwent coronary artery bypass graft (CABG) surgery. Post-operative blood lipid peroxides were found to be significantly higher (p < 0.001) than the preoperative value. Lipid peroxides raised to a peak value of 46.42 +/- 12.86 n mol/g Alb at 5 min of reperfusion when compared to the basal value and afterwards the level declined to 41.02 +/- 7.09 at 2 hrs and remained in that level even at 24 hrs of reperfusion. This increase implies an enhancement in free radical mediated oxidation of membrane lipids during bypass surgery and thus provides evidence for free radical generation during myocardial reperfusion.
N Jayakumari; K S Kumari; V Ambikakumari; Y Nazer; M P Singh; K G Balakrishnan; K S Iyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian heart journal     Volume:  45     ISSN:  0019-4832     ISO Abbreviation:  Indian Heart J     Publication Date:    1993 Nov-Dec
Date Detail:
Created Date:  1994-09-27     Completed Date:  1994-09-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374675     Medline TA:  Indian Heart J     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  489-91     Citation Subset:  IM    
Department of Biochemistry, Cardiology and Cardiac Surgery, SCTIMS, Trivandrum.
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MeSH Terms
Coronary Artery Bypass*
Coronary Disease / metabolism*,  surgery
Free Radicals
Lipid Peroxidation*
Lipid Peroxides / blood
Middle Aged
Myocardial Reperfusion
Myocardial Reperfusion Injury / etiology
Reg. No./Substance:
0/Free Radicals; 0/Lipid Peroxides

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