| Enhanced levels of CCL19 in patients with advanced acquired immune deficiency syndrome (AIDS). | |
| | |
MedLine Citation:
|
PMID: 22288592 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Based on the ability to recruit lymphocytes and dendritic cells to lymphoid tissue and to promote inflammation, we hypothesized a role for dysregulated CCL19 and CCL21 levels in human immunodeficiency virus (HIV)-infected patients with advanced immunodeficiency, and in particular in those with accompanying Mycobacterium avium complex (MAC) infection. The hypothesis was explored by studies in HIV-infected patients with and without MAC infection, as well as in vitro, examining the ability of proteins from MAC to promote CCL19 and CCL21 responses in peripheral blood mononuclear cells (PBMC) during highly active anti-retroviral therapy (HAART). Our main findings were: (i) raised serum levels of CCL19 in HIV-infected patients with CD4(+) T cell count <50 cells/µl compared with HIV-infected patients with CD4(+) T cell count >500 cells/µl and healthy controls, with particularly high levels in those with MAC infection; (ii) elevated plasma levels of CCL19 predicted a higher mortality in acquired immune deficiency syndrome (AIDS)-patients, independent of ongoing MAC infection; and (iii) marked production of CCL19 in MAC-stimulated peripheral blood mononuclear cells (PBMC) and pronounced disturbances in MAC-induced CCL19 production in PBMC from HIV patients that was partly reversed during HAART. Our findings suggest the involvement of CCL19 in AIDS patients with advanced immunodeficiency, potentially mediating both adaptive and maladaptive responses. |
| | |
Authors:
|
J K Damås; O Øktedalen; T Ueland; L Landrø; J Barstad; F Müller; S S Frøland; T H Flo; P Aukrust |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical and experimental immunology Volume: 167 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-01-31 Completed Date: 2012-03-22 Revised Date: 2013-04-15 |
Medline Journal Info:
|
Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 492-8 Citation Subset: IM |
Copyright Information:
|
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology. |
Affiliation:
|
Department of Infectious Diseases, St Olav's Hospital, Trondheim, Norway. jan.k.damas@ntnu.no |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
AIDS-Related Opportunistic Infections
/
blood,
immunology Acquired Immunodeficiency Syndrome / blood, drug therapy, immunology* Adult Antiretroviral Therapy, Highly Active Bacterial Proteins / immunology Biological Markers / blood Case-Control Studies Chemokine CCL19 / blood* Chemokine CCL21 / blood Female Humans Leukocytes, Mononuclear / immunology, microbiology Male Middle Aged Mycobacterium avium Complex / immunology Mycobacterium avium-intracellulare Infection / blood, immunology Prognosis |
| Chemical | |
Reg. No./Substance:
|
0/Bacterial Proteins; 0/Biological Markers; 0/CCL19 protein, human; 0/CCL21 protein, human; 0/Chemokine CCL19; 0/Chemokine CCL21 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The European internet-based patient and research database for primary immunodeficiencies: update 201...
Next Document: Impaired phagocytosis among patients infected by the human immunodeficiency virus: implication for a...