Document Detail

Enhanced level of micronuclei in peripheral blood lymphocytes of patients treated for restenosis with 32P endovascular brachytherapy.
MedLine Citation:
PMID:  18606378     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Restenosis is the complete occlusion of the blood vessel leading to such complications as ischemia/angina, myocardial infarction, and death. It can be managed by endovascular brachytherapy with both gamma and beta sources. Endovascular brachytherapy is performed worldwide on several thousands of cases per year. The gamma-emitter 192Ir as well as the beta-emitters 32P and 90Sr are mainly used. The dose to the occluded endothelial wall is 20 Gy. Interestingly, no information with respect to the dose absorbed by the blood during the course of the treatment exists. The aim of the present investigation was to verify if the micronucleus test is suitable to detect the dose absorbed by lymphocytes in the course of endovascular brachytherapy with 32P. MATERIALS AND METHODS: Blood was drawn from 16 patients immediately before and 1 day after the treatment. Frequencies of micronuclei were assessed. In order to ensure that the micronuclei did not arise due to fluoroscopy or reperfusion, we analyzed lymphocytes of 16 control patients who underwent interventional cardiology with balloon angioplasty only. RESULTS AND CONCLUSIONS: Enhanced frequencies of micronuclei were observed in lymphocytes of some donors following brachytherapy. No correlation could be detected between the level of induced micronuclei and the absorbed dose. Also, no effect of fluoroscopy or reperfusion was seen. Thus, although brachytherapy of restenosis with 32P leads to weak enhancement of the micronucleus frequency in lymphocytes, the effect was not seen in all patients; the reason for this heterogeneous response remains to be elucidated.
Andrzej Wojcik; Iwona Buraczewska; Sylwester Sommer; Kinga Brzozowska; Jerzy Pregowski; Adam Witkowski; Dariusz Garmol; Stanisław Pszona; Wojciech Bulski
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular revascularization medicine : including molecular interventions     Volume:  9     ISSN:  1553-8389     ISO Abbreviation:  -     Publication Date:    2008 Jul-Sep
Date Detail:
Created Date:  2008-07-08     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101238551     Medline TA:  Cardiovasc Revasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  IM    
Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, Warsaw, Poland.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary / methods*
Brachytherapy / methods*
Cells, Cultured
Coronary Restenosis / blood,  radiotherapy*
Follow-Up Studies
Lymphocytes / radiation effects,  ultrastructure*
Micronucleus, Germline / radiation effects*,  ultrastructure
Treatment Outcome

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