Document Detail

Enhanced intra-anastomotic healing by operative lavage with nutrient solutions in experimental left-sided colonic obstruction.
MedLine Citation:
PMID:  7613886     Owner:  NLM     Status:  MEDLINE    
The influence of intraoperative lavage with various solutions was tested on the healing of experimental colonic anastomoses performed in the presence of obstruction. After 24 h of ligature obstruction to the pelvic colon, male Wistar rats (n = 108) underwent colonic resection and primary anastomosis, using lavage with one of four different fluids: saline, povidone-iodine, 10 per cent hypertonic glucose and short-chain fatty acids (SCFA). Controls had no lavage. The anastomotic segment was excised and studied after 3 or 6 days. At day 3, mean(s.d.) bursting pressure was significantly greater in animals receiving SCFA compared with controls (81.2(23.0) mmHg versus 34.8(34.0) mmHg). Mean(s.d.) bowel wall tension was higher in rats with SCFA (30.6(8.1) N/m x 10(-4) or hypertonic glucose (29.5(10.1) N/m x 10(-4) compared with controls (12.2(12.1) N/m x 10(-4). By day 6, the anastomosis was more resistant to intraluminal pressure in each lavage group; mean(s.d.) hydroxyproline concentration at the anastomosis was greater in rats with SCFA (12.4(1.5) micrograms/mg) or hypertonic glucose (11.6(2.9) micrograms/mg) than in controls (8.9(1.5) micrograms/mg). Anastomotic healing is improved by all types of intraoperative colonic lavage, particularly with SCFA and hypertonic glucose solutions.
J E Aguilar-Nascimento; R T Mathie; W K Man; R C Williamson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of surgery     Volume:  82     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-22     Completed Date:  1995-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  461-4     Citation Subset:  AIM; IM    
Department of Surgery, Royal Postgraduate Medical School, London, UK.
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MeSH Terms
Anastomosis, Surgical
Colon / chemistry
Colonic Diseases / surgery*
Fatty Acids / administration & dosage
Hydroxyproline / analysis
Intestinal Obstruction / surgery*
Rats, Wistar
Wound Healing*
Reg. No./Substance:
0/Fatty Acids; 51-35-4/Hydroxyproline
Comment In:
Br J Surg. 1995 Sep;82(9):1280   [PMID:  7552023 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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