Document Detail

Enhanced inflammation with high carbohydrate intake during recovery from eccentric exercise.
MedLine Citation:
PMID:  20364347     Owner:  NLM     Status:  MEDLINE    
Inflammation associated with adipose tissue is modulated by macronutrient availability. For example, glucose increases inflammation in obese but not lean individuals. Little is known about how macronutrient intake influences inflammation associated with muscle. The aim of this study was to determine the impact of macronutrient intake differences during recovery from eccentric exercise on the inflammatory response. The study was a cross-over design in which young men and women (n = 12) completed high and low carbohydrate (CHO) conditions. Both conditions consisted of six sets of ten maximal high-force eccentric contractions of the elbow flexors and extensors followed by a controlled diet for the first 8 h post-exercise. Glucose, insulin, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and C-reactive protein were measured from blood samples pre-exercise, 1.5, 4, 8, and 24 h post-exercise. Perceived muscle soreness, strength loss, and serum CK activity were measured through 120 h post-exercise. Perceived soreness was elevated (P < 0.001) at all time points post-exercise in both conditions and was higher (P < 0.05) in the high compared to the low CHO condition. IL-1beta increased (P = 0.05) 24 h post-exercise in the high compared to the low CHO condition. There was a trend (P = 0.06) for IL-6 to be elevated in the high compared to the low CHO condition. We conclude that inflammation induced by high-force eccentric exercise in skeletal muscle is greater when a high CHO compared to a low CHO diet is consumed during recovery.
Chris M Depner; Rochelle D Kirwan; Sara J Frederickson; Mary P Miles
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-04-03
Journal Detail:
Title:  European journal of applied physiology     Volume:  109     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1067-76     Citation Subset:  IM    
Department of Health and Human Development, Montana State University, Box 173540, Bozeman, MT 59717, USA.
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MeSH Terms
Dietary Carbohydrates / metabolism*
Muscle Weakness*
Muscle, Skeletal / physiopathology*
Myositis / physiopathology*
Physical Endurance*
Physical Exertion*
Recovery of Function
Reg. No./Substance:
0/Dietary Carbohydrates

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