| Enhanced immunogenicity of xenogenized tumor cells in rats pretreated with cyclophosphamide (author's transl) | |
| | |
MedLine Citation:
|
PMID: 6456215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Immunization with xenogenized tumor cells, tumor cells infected with murine leukemia viruses produced strong antitumor immunity. In this study, the immunogenicity of xenogenized tumor cells was compared in cyclophophamide-treated and nontreated rats. CY treatment 3 days before immunization with xenogenized tumor cells enhanced antitumor cell-mediated immunity and antibody responses. However, CY treatment after immunization had no effect. Transfer of thymus cells from normal rats before the tumor challenge abolished the CY-induced augmenting effect. From these results, it is suggested that the elimination of precursors of suppressor T-cells results in enhanced immunogenicity of xenogenized tumor cells. |
| | |
Authors:
|
M Terashima |
Publication Detail:
|
Type: English Abstract; Journal Article |
Journal Detail:
|
Title: [Hokkaido igaku zasshi] The Hokkaido journal of medical science Volume: 55 ISSN: 0367-6102 ISO Abbreviation: Hokkaido Igaku Zasshi Publication Date: 1980 Nov |
Date Detail:
|
Created Date: 1981-11-22 Completed Date: 1981-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 17410290R Medline TA: Hokkaido Igaku Zasshi Country: JAPAN |
Other Details:
|
Languages: jpn Pagination: 495-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adjuvants, Immunologic* Animals Antibody Formation / drug effects Cyclophosphamide / administration & dosage, pharmacology* Friend murine leukemia virus Immunity, Cellular / drug effects* Leukemia, Experimental / immunology* Male Neoplasm Transplantation Rats T-Lymphocytes, Regulatory / immunology Transplantation, Heterologous |
| Chemical | |
Reg. No./Substance:
|
0/Adjuvants, Immunologic; 50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Laparoscopic transhepatic manometry in portal hypertension in patients with alcoholic liver damage.
Next Document: Fibrinogen degradation by two neutral granulocyte proteinases. Influence of calcium on the generatio...