Document Detail


Enhanced immunogenicity of xenogenized tumor cells in rats pretreated with cyclophosphamide (author's transl)
MedLine Citation:
PMID:  6456215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunization with xenogenized tumor cells, tumor cells infected with murine leukemia viruses produced strong antitumor immunity. In this study, the immunogenicity of xenogenized tumor cells was compared in cyclophophamide-treated and nontreated rats. CY treatment 3 days before immunization with xenogenized tumor cells enhanced antitumor cell-mediated immunity and antibody responses. However, CY treatment after immunization had no effect. Transfer of thymus cells from normal rats before the tumor challenge abolished the CY-induced augmenting effect. From these results, it is suggested that the elimination of precursors of suppressor T-cells results in enhanced immunogenicity of xenogenized tumor cells.
Authors:
M Terashima
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  [Hokkaido igaku zasshi] The Hokkaido journal of medical science     Volume:  55     ISSN:  0367-6102     ISO Abbreviation:  Hokkaido Igaku Zasshi     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-11-22     Completed Date:  1981-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  17410290R     Medline TA:  Hokkaido Igaku Zasshi     Country:  JAPAN    
Other Details:
Languages:  jpn     Pagination:  495-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic*
Animals
Antibody Formation / drug effects
Cyclophosphamide / administration & dosage,  pharmacology*
Friend murine leukemia virus
Immunity, Cellular / drug effects*
Leukemia, Experimental / immunology*
Male
Neoplasm Transplantation
Rats
T-Lymphocytes, Regulatory / immunology
Transplantation, Heterologous
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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