Document Detail

Enhanced homosynaptic LTD in cerebellar Purkinje cells of the dystrophic MDX mouse.
MedLine Citation:
PMID:  19722255     Owner:  NLM     Status:  MEDLINE    
The purpose was to study homosynaptic long-term depression (LTD) at the parallel fiber-Purkinje cell synapse in the mdx mouse, a murine model of the human dystrophinopathy, Duchenne muscular dystrophy (DMD), in order to examine whether the absence of dystrophin affects the induction and extent of this form of synaptic plasticity. Sharp intracellular electrodes were used to record electrically evoked excitatory postsynaptic potentials (EPSPs) from identified Purkinje cells in cerebellar slices. The early phase of homosynaptic LTD, 7-16 min postinduction, was the same in mdx and wildtype Purkinje cells; however, the late phase of LTD, 35-44 min, was significantly enhanced in mdx Purkinje cells. We hypothesize that this enhancement of the late phase of homosynaptic LTD may be due to a disruption of Ca(2+) homeostasis associated with the absence of the protein dystrophin. These findings may explain some of the central nervous system deficiencies reported in DMD boys.
Jennifer L Anderson; John W Morley; Stewart I Head
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  41     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  IM    
School of Medical Sciences, University of New South Wales, Sydney 2052, Australia.
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MeSH Terms
Analysis of Variance
Cerebellum / physiopathology*
Disease Models, Animal
Dystrophin / genetics
Excitatory Postsynaptic Potentials / genetics
Long-Term Synaptic Depression / genetics*
Membrane Potentials / genetics
Mice, Inbred mdx
Purkinje Cells / physiology*
Reg. No./Substance:

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