| Enhanced histamine metabolism: a comparative analysis of collagenous colitis and food allergy with respect to the role of diet and NSAID use. | |
| | |
MedLine Citation:
|
PMID: 12755379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES AND DESIGN: To compare clinical data and histamine metabolism of patients with collagenous colitis with those of food allergy. METHODS: In 17 patients with collagenous colitis, clinical findings (diarrhoea, abdominal pain) were recorded. Plasma (for histamine) and 12-h-urine (for histamine and n-methylhistamine, all measured by RIA) were collected during two days with an unrestricted diet followed by two days with an hypoallergenic. The clinical data and measured values were compared with those from patients with confirmed food allergy (n = 21) and controls (n = 41). RESULTS: Patients with collagenous colitis were found to present with significantly more liquid stools than patients with food allergy (p < 0.001) during both types of diet, but they did not experience more abdominal pain. N-methylhistamine in 12-h-urine was significantly increased during both types of diet in patients with collagenous colitis and food allergy when compared with controls (p < 0.001 for all). Patients with food allergy--but not those with collagenous colitis--showed a significant decrease of severity of pain (p < 0.05) when the diet was changed to the elimination protocol. CONCLUSION: Histamine is extensively produced and metabolised in patients with collagenous colitis. In contrast to food allergy, the allergenic potency of the administered food seems not to influence histamine production in collagenous colitis. However, histamine metabolism corresponds with the clinical activity in both patients with food allergy and collagenous colitis. |
| | |
Authors:
|
D Schwab; E G Hahn; M Raithel |
Related Documents
:
|
19674349 - Shellfish allergy in children. 14752339 - Animal models of food allergy. 7960479 - Handedness and allergic response. 3338599 - Are nailfold capillary changes indicators of organ involvement in progressive systemic ... 16550669 - Honey dressing versus paraffin tulle gras following toenail surgery. 3722649 - Effectiveness of dietary manipulation in the prevention of food allergy in infants. 11838919 - A longitudinal model of intake symptomatology, aa participation and outcome: retrospect... 1631179 - Effects of neuropeptide y on food-reinforced behavior in satiated rats. 21462589 - Ochratoxin a exposure assessment of the inhabitants of lisbon during winter 2007/2008 t... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
|
Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.] Volume: 52 ISSN: 1023-3830 ISO Abbreviation: Inflamm. Res. Publication Date: 2003 Apr |
Date Detail:
|
Created Date: 2003-05-20 Completed Date: 2003-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9508160 Medline TA: Inflamm Res Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 142-7 Citation Subset: IM |
Affiliation:
|
Department of Medicine 1, Ulmenweg 18, Friedrich-Alexander-University Erlangen-Nürnberg, 91054 Erlangen, Germany. Dieter.Schwab@med1.imed.uni-erlangen.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Anti-Inflammatory Agents, Non-Steroidal / adverse effects* Colitis / metabolism*, pathology Diet* Female Food Hypersensitivity / metabolism*, pathology Histamine / blood, metabolism*, urine Humans Male Mast Cells / pathology, physiology Methylhistamines / blood, urine Middle Aged Pain Measurement Radioimmunoassay |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Methylhistamines; 51-45-6/Histamine; 673-50-7/N-methylhistamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analysis of the inflammatory response in the rat paw caused by the venom of Apis melifera bee.
Next Document: Impact of topoisomerase II inhibition on cytokine and chemokine production.