| Enhanced growth inhibition effect of resveratrol incorporated into biodegradable nanoparticles against glioma cells is mediated by the induction of intracellular reactive oxygen species levels. | |
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MedLine Citation:
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PMID: 19395246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Resveratrol (Res) has been reported to elicit many cellular responses including cell cycle arrest, differentiation, and apoptosis. This makes it a novel and potential anticancer agent. Moreover, the lipophilicity of Res raises the possibility of its application as a potential model drug in nanoparticle based delivery systems. Resveratrol is incorporated into mPEG-PCL based nanoparticles with high encapsulation efficiency due to its lipophilicity. The significant finding of the current study is that Res-loaded nanoparticles at lower concentration could lead to significantly higher cell death compared to equivalent dose of free Res and this difference of cytotoxicity could not be abrogated by the antioxidant Vitamin E. Furthermore, free Res shows significant less cytotoxicity than the equivalent dose of Res-loaded nanoparticles with the preconditioning of Vitamin E. Meanwhile, reactive oxygen species (ROS) determination revealed the significantly lower intracellular ROS levels in Res-treated cells compared to nanoparticle-treated cells. Therefore, the differential cytotoxicity between Res and Res-loaded nanoparticles may be mediated by the discrepancy of intracellular ROS levels. The present results suggest that Res-loaded nanoparticles could be a potential useful chemotherapeutic formulation for malignant glioma therapy and the development of traditional Chinese medicine with nanoscale drug formation warrants more intensive research in order to evaluate its clinical feasibility. |
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Authors:
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Junfei Shao; Xiaolin Li; Xiaowei Lu; Chen Jiang; Yong Hu; Qingping Li; Yongping You; Zhen Fu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-27 |
Journal Detail:
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Title: Colloids and surfaces. B, Biointerfaces Volume: 72 ISSN: 1873-4367 ISO Abbreviation: Colloids Surf B Biointerfaces Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-06-03 Completed Date: 2009-07-29 Revised Date: 2009-10-16 |
Medline Journal Info:
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Nlm Unique ID: 9315133 Medline TA: Colloids Surf B Biointerfaces Country: Netherlands |
Other Details:
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Languages: eng Pagination: 40-7 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, the People's Hospital of Wuxi Affiliated to Nanjing Medical University, Wuxi, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biodegradation, Environmental / drug effects Cell Death / drug effects Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Dose-Response Relationship, Drug Drug Carriers Glioma / pathology* Intracellular Space / drug effects*, metabolism* Microscopy, Fluorescence Nanoparticles / chemistry*, ultrastructure Particle Size Rats Reactive Oxygen Species / metabolism* Stilbenes / pharmacology* Vitamin E / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Reactive Oxygen Species; 0/Stilbenes; 1406-18-4/Vitamin E; 501-36-0/resveratrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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