| Enhanced gene transfection capability of polyethylenimine by incorporating boronic acid groups. | |
| | |
MedLine Citation:
|
PMID: 20625601 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Phenylboronic acid-modified PEI was prepared by the reaction of 1800 Da PEI with 4-(bromomethyl)phenylboronic acid. It is much more effective than unmodified PEI for gene delivery. The covalently incorporated boronic acid groups achieve the greatly enhanced gene delivery efficiency partially through improving condensation ability to DNA, and partially through facilitating cell uptake due to interaction with ligands in cells. |
| | |
Authors:
|
Qi Peng; Fujie Chen; Zhenlin Zhong; Renxi Zhuo |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-13 |
Journal Detail:
|
Title: Chemical communications (Cambridge, England) Volume: 46 ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-05 Completed Date: 2010-11-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: England |
Other Details:
|
Languages: eng Pagination: 5888-90 Citation Subset: IM |
Affiliation:
|
Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Boronic Acids / chemistry* COS Cells Cercopithecus aethiops Fluorescein-5-isothiocyanate / chemistry Fluorescent Dyes / chemistry Hep G2 Cells Humans Plasmids / chemistry, metabolism Polyethyleneimine / chemistry* Transfection / methods* |
| Chemical | |
Reg. No./Substance:
|
0/Boronic Acids; 0/Fluorescent Dyes; 3326-32-7/Fluorescein-5-isothiocyanate; 9002-98-6/Polyethyleneimine; 98-80-6/benzeneboronic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabolically incorporated photocrosslinking sialic acid covalently captures a ganglioside-protein c...
Next Document: CuInS2 nanotube array on indium tin oxide: synthesis and photoelectrochemical properties.