Document Detail


Enhanced gene transfection capability of polyethylenimine by incorporating boronic acid groups.
MedLine Citation:
PMID:  20625601     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phenylboronic acid-modified PEI was prepared by the reaction of 1800 Da PEI with 4-(bromomethyl)phenylboronic acid. It is much more effective than unmodified PEI for gene delivery. The covalently incorporated boronic acid groups achieve the greatly enhanced gene delivery efficiency partially through improving condensation ability to DNA, and partially through facilitating cell uptake due to interaction with ligands in cells.
Authors:
Qi Peng; Fujie Chen; Zhenlin Zhong; Renxi Zhuo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-13
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  46     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  5888-90     Citation Subset:  IM    
Affiliation:
Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Boronic Acids / chemistry*
COS Cells
Cercopithecus aethiops
Fluorescein-5-isothiocyanate / chemistry
Fluorescent Dyes / chemistry
Hep G2 Cells
Humans
Plasmids / chemistry,  metabolism
Polyethyleneimine / chemistry*
Transfection / methods*
Chemical
Reg. No./Substance:
0/Boronic Acids; 0/Fluorescent Dyes; 3326-32-7/Fluorescein-5-isothiocyanate; 9002-98-6/Polyethyleneimine; 98-80-6/benzeneboronic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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