Document Detail


Enhanced function in the good forelimb of hemi-parkinson rats: compensatory adaptation for contralateral postural instability?
MedLine Citation:
PMID:  18417125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this paper we present two new assays of rat motor behavior which can be used to assess function linked to postural stability in each forelimb independently. Postural instability is a major deficit in Parkinson's disease that is resistant to levodopa therapy and contributes to the risk of falling. We applied both tests, one forelimb at a time, to normal rats as well as rats extensively depleted of dopamine by unilateral infusion of 6-hydroxydopamine (6-OHDA, given in the medial forebrain bundle) to produce a hemi-parkinsonian syndrome. The 6-OHDA rats showed severe postural instability in the impaired forelimb, but unexpectedly showed enhanced function in the non-impaired forelimb. The data suggest that the intact hemisphere may undergo rapid reorganization subsequent to unilateral dopamine depletion, which allows for compensatory function of the "intact" limb. Measurements of amphetamine-induced striatal c-fos expression, as well as behavior results gathered when animals were under the influence of apomorphine or haloperidol, indicate that this potential reorganization may require non-dopaminergic neural plasticity. The relevance of these findings for unilateral rat models of neurological disease is discussed.
Authors:
Martin T Woodlee; Jacqueline R Kane; Jitsen Chang; Lawrence K Cormack; Timothy Schallert
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-03-18
Journal Detail:
Title:  Experimental neurology     Volume:  211     ISSN:  1090-2430     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-07-07     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  511-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology*
Animals
Forelimb / physiology*
Functional Laterality / physiology*
Male
Parkinson Disease / physiopathology*
Postural Balance / physiology*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
NS-19608/NS/NINDS NIH HHS; P50 NS019608/NS/NINDS NIH HHS; P50 NS019608-19A1/NS/NINDS NIH HHS; P50 NS024707/NS/NINDS NIH HHS
Comments/Corrections

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