Document Detail


Enhanced food-related motivation after bilateral lesions of the subthalamic nucleus.
MedLine Citation:
PMID:  11784803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although inactivation of the subthalamic nucleus (STN) has beneficial effects on motor symptoms of parkinsonism, little is known of possible actions on nonmotor symptoms of cognition or mood. Here, we used several forms of converging evidence to show that STN lesions can enhance behavioral motivation. Thus, bilateral fiber-sparing lesions of the STN in rats reduced the time required to eat a standard number of food reward pellets, without affecting food intake, and altered performance on a number of behavioral measures consistent with enhanced motivation for food. Thus, STN-lesioned rats showed greater levels of locomotor activity conditioned to food presentation, enhanced control over responding by food-related conditioned reinforcers, and a higher breaking point associated with elevated rate of lever press under a progressive ratio schedule of reinforcement. These results reveal a new functional role schedule for STN, possibly because of its involvement in ventral, as well as dorsal, striatal circuitry and are relevant to the therapeutic effects of STN stimulation in Parkinson's disease.
Authors:
Christelle Baunez; Marianne Amalric; Trevor W Robbins
Related Documents :
9694533 - Choice maintained by cocaine or food in monkeys: effects of varying probability of rein...
16812763 - Within-session changes in key and lever pressing for water during several multiple vari...
24210973 - A content analysis of food references in television programming specifically targeting ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  22     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-10     Completed Date:  2002-01-30     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  562-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Appetitive Behavior / physiology
Behavior, Animal / physiology
Conditioning (Psychology)
Consummatory Behavior / physiology*
Eating / physiology
Feeding Behavior / physiology*
Male
Motivation*
Motor Activity / physiology
Rats
Rats, Long-Evans
Reaction Time / physiology*
Reinforcement (Psychology)
Reward
Subthalamic Nucleus / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Functional connectivity of human premotor and motor cortex explored with repetitive transcranial mag...
Next Document:  Lid restraint evokes two types of motor adaptation.