Document Detail

Enhanced flow velocity increase through the left ventricular inflow tract of patients with isolated aortic regurgitation.
MedLine Citation:
PMID:  1536116     Owner:  NLM     Status:  MEDLINE    
Twenty-five patients with chronic aortic regurgitation (AR), and 12 control subjects were studied using Doppler echocardiography to investigate the effects of AR on transmitral flow. Peak early filling velocities at the levels of the mitral valve tips (E1) and annulus (E2) were measured, and the transmitral flow restriction index (delta E = (E1-E2)/E2) was obtained. Patients with AR were classified into 2 groups according to the ratio of the cross-sectional area of the regurgitant jet to that of the left ventricular outflow tract. Group I had the ratio less than 0.20, and group II had greater than or equal to 0.20. E2 in group II was lower than in control subjects, whereas E1 was not significantly different in any groups. delta E in group II was higher than in group I or in control subjects (p less than 0.05 and 0.01, respectively). delta E showed a significant correlation with the cross-sectional area ratio in all patients with AR (r = 0.70, p less than 0.01) and in group II (r = 0.82; p less than 0.01). Our data suggest that AR restricts early transmitral filling, and that delta E may indicate the increased driving pressure caused by flow restriction and is a useful hemodynamic index of AR.
T Oniki; Y Hashimoto; S Shimizu; M Iwakami; T Kato; W Aerbajinai; Y Kishi; M Yajima; F Numano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  69     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-03-26     Completed Date:  1992-03-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  654-7     Citation Subset:  AIM; IM    
Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Japan.
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MeSH Terms
Analysis of Variance
Aortic Valve Insufficiency / physiopathology*,  ultrasonography
Blood Flow Velocity
Echocardiography, Doppler
Linear Models
Middle Aged
Mitral Valve / physiopathology*,  ultrasonography

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