Document Detail

Enhanced fetal growth in sheep administered progesterone during the first three days of pregnancy.
MedLine Citation:
PMID:  7861395     Owner:  NLM     Status:  MEDLINE    
Two experiments were conducted to determine whether administration of progesterone during early pregnancy affects fetal growth in sheep and if any effect is specific to the days of treatment. In the first experiment, Merino ewes were randomly allocated to four treatment groups and inseminated at a synchronized oestrus. Three groups received progesterone on days 1-3, 3-6 or 1-6 of pregnancy while the fourth group was untreated. Concentrations of progesterone in peripheral plasma increased (P < 0.05) in all treatment groups. Fetal growth (to day 74) was greater in all treatment groups than in the control group (P < 0.001) and was greatest when treatments started on day 1. Pregnancy rate was not affected by progesterone treatment on days 3-6, but was reduced (P < 0.05) when treatment began on day 1. In the second experiment, embryos that had been exposed to either a normal (control) or a high concentration of progesterone on days 1-3 were randomly transferred, within groups, to recipient ewes that had or had not been treated with progesterone on days 1-3. In another group, embryos were exposed to a high concentration of progesterone on days 1-3 and the oviducts of the ewe were ligated. An increase in fetal mass was observed in the recipient group that had been treated with progesterone (P < 0.01) but was not observed in the initial group treated with progesterone. A greater fetal mass was also obtained when embryos that had been ligated in the oviducts of ewes treated with progesterone (P < 0.05) were transferred.(ABSTRACT TRUNCATED AT 250 WORDS)
D O Kleemann; S K Walker; R F Seamark
Related Documents :
21253125 - Hematological problems of pregnancy.
3162325 - Inhibition of 3 beta-hydroxysteroid dehydrogenase in the sow near term: effects on feta...
1849585 - Use of serum progesterone levels as an early, indirect evaluation of pregnancy in the t...
9685565 - European study on maternal and fetal management of fetal supraventricular tachyarrhythm...
16124455 - Factors affecting decision making of low-income young women with unplanned pregnancies ...
22399065 - First-trimester screening for spontaneous preterm delivery with maternal characteristic...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  102     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-03-23     Completed Date:  1995-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  411-7     Citation Subset:  IM    
South Australian Research and Development Institute, Turretfield Research Centre, Rosedale.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Crown-Rump Length
Embryo Transfer
Embryonic and Fetal Development / drug effects*
Fallopian Tubes
Fetus / anatomy & histology
Gestational Age
Litter Size / drug effects
Progesterone / pharmacology*
Sheep / physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Study of the role of epididymal alpha-glucosidase in the fertility of male rats by the administratio...
Next Document:  Presence of the complement-regulatory protein membrane cofactor protein (MCP, CD46) as a membrane-as...