Document Detail

Enhanced expression of membrane phosphoproteins tyrosine phosphorylation in estrogen-induced kidney tumors.
MedLine Citation:
PMID:  1632768     Owner:  NLM     Status:  MEDLINE    
We demonstrate for the first time that the expression of tyrosine containing membrane phosphoproteins is elevated in estrogen-induced kidney tumors, which is evident from both the types of experiments, i.e., alkali-resistant phosphorylation of membrane proteins and immunoprecipitation of tyrosine containing phosphoproteins. Tyrosine phosphorylation of proteins or peptides was modulated by the growth factors (EGF, IGF-I) and by the inhibitors of tyrosine protein kinase(s). The kinetic analyses revealed that tumor membranes have high affinity and catalytically more efficient tyrosine phosphorylating kinase enzyme(s) compared to that of normal membranes which have low affinity and catalytically less efficient kinase enzyme(s). It is proposed that overexpression of tyrosine containing membranal phosphoproteins may be involved in the induction and growth of estrogen-induced renal neoplasm.
S Narayan; D Roy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  186     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-14     Completed Date:  1992-08-14     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  228-36     Citation Subset:  IM    
Center for Molecular Sciences, University of Texas Medical Branch, Galveston 77550.
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MeSH Terms
Cell Membrane / enzymology
Electrophoresis, Polyacrylamide Gel
Epidermal Growth Factor / pharmacology
Ethylmaleimide / pharmacology
Insulin-Like Growth Factor I / pharmacology
Kidney / enzymology*
Kidney Neoplasms / chemically induced,  enzymology*
Molecular Weight
Neoplasm Proteins / isolation & purification,  metabolism
Phosphoproteins / isolation & purification,  metabolism*
Protein-Tyrosine Kinases / isolation & purification,  metabolism*
Quercetin / pharmacology
Rats, Inbred Strains
Reference Values
Grant Support
Reg. No./Substance:
0/Neoplasm Proteins; 0/Phosphoproteins; 117-39-5/Quercetin; 128-53-0/Ethylmaleimide; 56-53-1/Diethylstilbestrol; 62229-50-9/Epidermal Growth Factor; 67763-96-6/Insulin-Like Growth Factor I; EC Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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