Document Detail

Enhanced expression of cytokines/chemokines in cerebrospinal fluids in mumps meningitis in children.
MedLine Citation:
PMID:  21501303     Owner:  NLM     Status:  In-Data-Review    
Background:  The mumps virus is frequently the causative agent in aseptic meningitis and mumps has still prevailed in Japan. We compared data obtained from patients with mumps meningitis and patients with aseptic meningitis caused by other viruses in order to identify mumps meningitis-specific cytokine/chemokine alterations in cerebrospinal fluide (CSF). Methods:  We elucidated the cytokine/chemokine network based on the cytokine/chemokine profiles in CSF from children with mumps meningitis and meningitis due to other viral infections using multiplex cytokine measurement. Seventeen cytokines/chemokines, namely interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-13, IL-17, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, granulocyte colony-stimulating factor (G-CSF), granulocyte monocyte colony-stimulating factor (GM-CSF), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β), were measured simultaneously in CSF supernatants from eight children with mumps meningitis, 11 children with other types of viral meningitis and eight children with fever without neurological complications such as convulsion. Results:  We found that IL-8, IL-10, IL-12, IL-13 and IFN-γ showed a statistically significant increase in CSF from mumps meningitis when compared to other types of viral meningitis and fever without neurological complications. Conclusion:  Mumps meningitis may induce a distinct immunological response when compared with other types of viral meningitis.
Takeshi Asano; Kunihiko Ichiki; Shinya Koizumi; Kiyohiko Kaizu; Takayuki Hatori; Osamu Fujino; Kunihiro Mashiko; Yuichiro Sakamoto; Taku Miyasho; Yoshitaka Fukunaga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  53     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  143-6     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors.Pediatrics International © 2011 Japan Pediatric Society.
Departments of Pediatrics Emergency and Critical Care Medicine, Nippon Medical School, Chiba Hokusoh Hospital, Chiba Department of Veterinary Biochemistry School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
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