| Enhanced expression of glial fibrillary acidic protein in the hippocampus one month after whole brain irradiation of adult rats. | |
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MedLine Citation:
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PMID: 21427659 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the changes of glial fibrillary acidic protein in the hippocampus after whole brain irradiation of adult rats. METHODS: Forty-one male Sprague-Dawley rats (180-220 g weight and 6-8 weeks) were divided into the 9 irradiation subgroups, sham, and control groups. Their whole brain was irradiated by a single dose of 2, 10, and 30 Gy. At one day, one week, and one month after irradiation, reverse transcriptase-polymerase chain reaction assay was used to semiquantitatively analyze the expression of glial fibrillary acidic protein messenger RNA, and immunohistochemistry was performed to detect glial fibrillary acidic protein-positive cells. This study was carried out at The Second Affiliated Hospital of Soochow University, Jiangsu, China between October 2008 and November 2009. RESULTS: No obvious changes were found between the control and 2 Gy irradiation groups. However, glial fibrillary acidic protein messenger RNA levels were increased after one day and reached a higher level one month after 10 and 30 Gy irradiation. A significant increase in glial fibrillary acidic protein-positive astrocytes was detected one month after 30 Gy irradiation. CONCLUSION: Astrocytes may play an important role in the mechanisms underlying radiation-induced brain injuries in the early stages. |
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Authors:
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Ye Tian; Shu Yang; Liyuan Zhang; Zhige Shi; Shiyao Bao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurosciences (Riyadh, Saudi Arabia) Volume: 16 ISSN: 1319-6138 ISO Abbreviation: Neurosciences (Riyadh) Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101252453 Medline TA: Neurosciences (Riyadh) Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 114-9 Citation Subset: IM |
Affiliation:
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Department of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, Suzhou, Jiangsu 215004, China. Tel. +86 (512) 67783430. Fax. +86 (512) 68284303. E-mail: dryetian@hotmail.com. |
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