Document Detail

Enhanced exercise-induced plasma cytokine response and oxidative stress in COPD patients depend on blood oxygenation.
MedLine Citation:
PMID:  18312445     Owner:  NLM     Status:  MEDLINE    
In healthy subjects, hypoxemia and exercise represent independent stressors promoting the exercise-induced cytokine response and oxidative stress. We hypothesized that hypoxemia in patients with chronic obstructive pulmonary disease (COPD) may affect the cytokine production and/or the changes in oxidant-antioxidant status in response to maximal exercise. Exercise-induced changes in PaO2 allowed to transiently increase or decrease baseline hypoxemia and to point out its specific action on muscle metabolism. COPD patients with severe to moderate hypoxemia (56 < PaO2 < 72 mmHg) performed an incremental cycling exercise until volitional exhaustion. Two cytokines [interleukin (IL)-6 and tumour necrosis factor (TNF)-alpha] and three blood indices of oxidative stress [plasma thiobarbituric acid reactive substances (TBARS) and two antioxidants, reduced erythrocyte glutathione (GSH), and reduced plasma ascorbic acid, RAA] were measured at rest, then during and after exercise. The changes in the cytokine levels and oxidant-antioxidant status were analysed in relation with the baseline PaO2 and its exercise-induced variations. Data were compared with those obtained in an age- and body mass index-matched group of healthy subjects. Compared with healthy subjects, COPD patients presented a marked accentuation of exercise-induced increase in IL-6 level and earlier changes in their oxidant-antioxidant status. Resting levels of IL-6 and TNF-alpha and exercise-induced peak variations of TBARS, IL-6 and TNF-alpha were negatively correlated with the baseline PaO2. In COPD patients, the peak increases in IL-6 and TBARS were attenuated when exercise hyperventilation reduced the baseline hypoxemia. Our study indicates that the PaO2 level affects both the exercise-induced oxidative stress and cytokine response in hypoxemic COPD patients.
Yves Jammes; Jean Guillaume Steinberg; Abdoulaye Ba; Stéphane Delliaux; Fabienne Brégeon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-25
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  28     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-11     Completed Date:  2008-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  182-8     Citation Subset:  IM    
Lung Function Laboratory, North Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
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MeSH Terms
Anoxia / blood*,  etiology*,  physiopathology
Ascorbic Acid / blood
Biological Markers / blood
Case-Control Studies
Glutathione / blood
Interleukin-6 / blood*
Middle Aged
Oxidative Stress*
Oxygen / blood*
Pulmonary Disease, Chronic Obstructive / blood*,  complications,  physiopathology
Thiobarbituric Acid Reactive Substances / metabolism
Time Factors
Tumor Necrosis Factor-alpha / blood*
Reg. No./Substance:
0/Biological Markers; 0/IL6 protein, human; 0/Interleukin-6; 0/Thiobarbituric Acid Reactive Substances; 0/Tumor Necrosis Factor-alpha; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione; 7782-44-7/Oxygen

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