| Enhanced exercise-induced plasma cytokine response and oxidative stress in COPD patients depend on blood oxygenation. | |
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MedLine Citation:
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PMID: 18312445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In healthy subjects, hypoxemia and exercise represent independent stressors promoting the exercise-induced cytokine response and oxidative stress. We hypothesized that hypoxemia in patients with chronic obstructive pulmonary disease (COPD) may affect the cytokine production and/or the changes in oxidant-antioxidant status in response to maximal exercise. Exercise-induced changes in PaO2 allowed to transiently increase or decrease baseline hypoxemia and to point out its specific action on muscle metabolism. COPD patients with severe to moderate hypoxemia (56 < PaO2 < 72 mmHg) performed an incremental cycling exercise until volitional exhaustion. Two cytokines [interleukin (IL)-6 and tumour necrosis factor (TNF)-alpha] and three blood indices of oxidative stress [plasma thiobarbituric acid reactive substances (TBARS) and two antioxidants, reduced erythrocyte glutathione (GSH), and reduced plasma ascorbic acid, RAA] were measured at rest, then during and after exercise. The changes in the cytokine levels and oxidant-antioxidant status were analysed in relation with the baseline PaO2 and its exercise-induced variations. Data were compared with those obtained in an age- and body mass index-matched group of healthy subjects. Compared with healthy subjects, COPD patients presented a marked accentuation of exercise-induced increase in IL-6 level and earlier changes in their oxidant-antioxidant status. Resting levels of IL-6 and TNF-alpha and exercise-induced peak variations of TBARS, IL-6 and TNF-alpha were negatively correlated with the baseline PaO2. In COPD patients, the peak increases in IL-6 and TBARS were attenuated when exercise hyperventilation reduced the baseline hypoxemia. Our study indicates that the PaO2 level affects both the exercise-induced oxidative stress and cytokine response in hypoxemic COPD patients. |
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Authors:
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Yves Jammes; Jean Guillaume Steinberg; Abdoulaye Ba; Stéphane Delliaux; Fabienne Brégeon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-25 |
Journal Detail:
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Title: Clinical physiology and functional imaging Volume: 28 ISSN: 1475-0961 ISO Abbreviation: Clin Physiol Funct Imaging Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-11 Completed Date: 2008-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137604 Medline TA: Clin Physiol Funct Imaging Country: England |
Other Details:
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Languages: eng Pagination: 182-8 Citation Subset: IM |
Affiliation:
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Lung Function Laboratory, North Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France. yves.jammes@univmed.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anoxia / blood*, etiology*, physiopathology Ascorbic Acid / blood Biological Markers / blood Case-Control Studies Exercise* Female Glutathione / blood Humans Interleukin-6 / blood* Male Middle Aged Oxidative Stress* Oxygen / blood* Pulmonary Disease, Chronic Obstructive / blood*, complications, physiopathology Thiobarbituric Acid Reactive Substances / metabolism Time Factors Tumor Necrosis Factor-alpha / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/IL6 protein, human; 0/Interleukin-6; 0/Thiobarbituric Acid Reactive Substances; 0/Tumor Necrosis Factor-alpha; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione; 7782-44-7/Oxygen |
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