Document Detail


Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion.
MedLine Citation:
PMID:  10601467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pain and hyperalgesia can occur when the dorsal root ganglion (DRG) and its roots are deformed mechanically in association with injuries or diseases of the spine. To evaluate the electrophysiological changes that contribute to this sensory pathology, intracellular recordings were obtained in vitro from DRGs that had received a chronic mechanical compression [chronic compression of DRG (CCD)]. The compression was produced by inserting L-shaped rods ipsilaterally into the intervertebral foramina, one at L(4) and the other at L(5) in rats 1-14 days before the recording. Control rats received a sham operation. Postoperatively, the threshold force applied by punctate stimulation of the plantar surface of the hind paw decreased significantly on the foot ipsilateral to the CCD (mechanical hyperalgesia) but changed little on the contralateral foot or on either foot for control rats. DRG somata were viewed through a microscope during recording and classified as small, medium, and large according to their diameters. CCD cells in each size category were more excitable than those of comparable size from control rats as judged by the significantly lowered threshold currents and action potential voltage thresholds. Spontaneous activity was recorded in 11% of all the CCD cells tested. The spontaneous activity and/or changes in both the threshold currents and action potential thresholds were observed as early as one day after injury. The association of cutaneous hyperalgesia with changes in the electrophysiological properties of DRG cells suggests a possible role for intrinsic alterations in the membrane properties of compressed DRG cells in the production and persistence of chronic pain after certain spinal injuries or pathologies of the spine.
Authors:
J M Zhang; X J Song; R H LaMotte
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurophysiology     Volume:  82     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3359-66     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / physiology
Behavior, Animal / physiology
Chronic Disease
Female
Ganglia, Spinal / physiopathology*
Hyperalgesia / physiopathology*,  psychology
Nerve Compression Syndromes / physiopathology*
Neural Conduction / physiology
Neurons, Afferent / physiology*
Pain Measurement
Pain Threshold / physiology
Physical Stimulation
Prostheses and Implants
Rats
Rats, Sprague-Dawley
Sciatic Nerve / physiology
Grant Support
ID/Acronym/Agency:
NS-10174/NS/NINDS NIH HHS; NS-14624/NS/NINDS NIH HHS

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