| ENHANCED ENDOTHELIN-1 SYSTEM ACTIVITY WITH OVERWEIGHT AND OBESITY. | |
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MedLine Citation:
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PMID: 21666117 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Endothelin-1-mediated vasoconstrictor tone contributes to the development and progression of several adiposity-related conditions, including hypertension and atherosclerotic vascular disease. The aims of the present study were to determine: 1) whether endogenous endothelin-1 vasoconstrictor activity is elevated in overweight and obese adults; and, if so, 2) whether increased endothelin-1-mediated vasoconstriction contributes to the adiposity-related impairment in endothelium-dependent vasodilation. Seventy-nine adults were studied: 34 normal weight (BMI <25 kg/m(2)); 22 overweight (BMI ≥25<30 kg/m(2)); and 23 obese (BMI ≥30 kg/m(2)). Forearm blood flow responses to intra-arterial infusion of endothelin-1 (5 pmol/min; for 20 min) and selective endothelin-1 receptor blockade (BQ-123; 100 nmol/min; for 60 min) were determined. In a subset of the study population, forearm blood flow responses to acetylcholine (4.0, 8.0, and 16.0 μg/100 mL tissue/min) were measured in the absence and presence of selective endothelin-1 receptor blockade. The vasoconstrictor response to endothelin-1 was significantly blunted in the overweight and obese (~70%) compared with normal weight adults. Selective endothelin-1 receptor blockade elicited a significant vasodilator response (~20%) in the overweight and obese adults, but did not alter forearm blood flow in the normal weight adults. Co-infusion of BQ-123 did not affect forearm blood flow responses to acetylcholine in normal weight adults, but resulted in an ~20% increase (P<0.05) in acetylcholine-induced vasodilation in overweight and obese adults. These results demonstrate that overweight and obesity are associated with enhanced endothelin-1-mediated vasoconstriction that contributes to endothelial vasodilator dysfunction and may play a role in the increased prevalence of hypertension with increased adiposity. |
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Authors:
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Brian R Weil; Christian M Westby; Gary P Van Guilder; Jared J Greiner; Brian L Stauffer; Christopher A Desouza |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-10 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Colorado. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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