Document Detail

Enhanced dopamine release by nicotine in cigarette smokers: a double-blind, randomized, placebo-controlled pilot study.
MedLine Citation:
PMID:  17949514     Owner:  NLM     Status:  MEDLINE    
Previous studies of smoking on dopamine release in humans were investigated only in smokers. Using nicotine gum, we examined the effect of nicotine on dopamine release in smokers and non-smokers and its relation to the degree of nicotine dependence. Smokers and non-smokers participated in a double-blind, randomized, placebo-controlled cross-over study. They participated in two PET measurements with [11C]raclopride, in which they received either nicotine or placebo. Changes in [11C]raclopride non-displaceable binding potential (BPND) following nicotine administration were quantified. Smokers showed significant decrease in BP in the striatum following nicotine administration, but non-smokers did not show such a decrease. The BPND difference between the two scanning sessions was correlated with the degree of nicotine dependence. The BPND difference might reflect enhanced dopamine release in smokers and the reinforced effect of nicotine. These data suggest the feasibility of our gum method as well as the importance of the degree of dependence in future studies of the nicotine effect on the dopamine system.
Hidehiko Takahashi; Yota Fujimura; Mika Hayashi; Harumasa Takano; Motoichiro Kato; Yoshiro Okubo; Iwao Kanno; Hiroshi Ito; Tetsuya Suhara
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-10-22
Journal Detail:
Title:  The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)     Volume:  11     ISSN:  1461-1457     ISO Abbreviation:  Int. J. Neuropsychopharmacol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-02     Completed Date:  2008-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815893     Medline TA:  Int J Neuropsychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  413-7     Citation Subset:  IM    
Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Anagawa, Inage-ku, Chiba, Japan.
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MeSH Terms
Dopamine / metabolism*
Dopamine Antagonists / diagnostic use
Double-Blind Method
Neostriatum / drug effects,  radionuclide imaging
Nicotine / administration & dosage,  analogs & derivatives*
Nicotinic Agonists / administration & dosage*
Pilot Projects
Polymethacrylic Acids / administration & dosage*
Polyvinyls / administration & dosage*
Positron-Emission Tomography
Raclopride / diagnostic use
Smoking / drug therapy*,  metabolism*
Reg. No./Substance:
0/Dopamine Antagonists; 0/Nicotinic Agonists; 0/Polymethacrylic Acids; 0/Polyvinyls; 54-11-5/Nicotine; 84225-95-6/Raclopride; 96055-45-7/nicotine polacrilex

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