| Enhanced degradation of tryptophan in patients on hemodialysis. | |
| | |
MedLine Citation:
|
PMID: 21084050 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Hemodialysis patients often present with increased concentrations of tryptophan catabolites perhaps related to an enhanced activity of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) that is inducible by pro-inflammatory stimuli. The often chronic inflammation and immune activation status in dialysis patients may accelerate tryptophan degradation, which could influence patients' psychological performance. PATIENTS AND METHODS: In this study, plasma concentrations of kynurenine and tryptophan were determined by HPLC in 75 dialysis patients, aged 65.3 ± 15.0 years. Forty patients were female, 35 male; 21 (28%) had diabetes mellitus Type 1 or 2 and 32 (43%) suffered from sleep disturbances and/or depression. Their dialysis vintage was 4.26 ± 4.72 years. HPLC results were compared to concentrations obtained from 40 healthy blood donors, to immune activation marker neopterin, and to psychological test results based on INTERMED scores. RESULTS: Compared to those in healthy controls, tryptophan concentrations were decreased in patients. Neopterin, kynurenine and the kynurenine to tryptophan ratio (kyn/trp, an index of tryptophan degradation) were increased in patients (all p < 0.01). Kyn/trp correlated with neopterin concentrations (rs = 0.393, p < 0.01). INTERMED scores were 21.0 + 8.4 and slightly higher in females (U = -1.831, p < 0.07); they correlated with tryptophan concentrations (rs = -0.227, p < 0.05) but with no other parameter studied. Data point to a possible relationship between tryptophan metabolic disturbances and psychologic presentation of patients, although only a rather weak relationship was found. CONCLUSION: We conclude that tryptophan degradation is increased in dialysis patients. The association with increased neopterin concentrations indicates activated IDO. |
| | |
Authors:
|
P Koenig; C Nagl; G Neurauter; H Schennach; G Brandacher; D Fuchs |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical nephrology Volume: 74 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-18 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: Germany |
Other Details:
|
Languages: eng Pagination: 465-70 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Innsbruck Medical University, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Austria Biological Markers / blood Case-Control Studies Chromatography, High Pressure Liquid Enzyme Activation Female Humans Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism Kynurenine / blood Male Middle Aged Neopterin / blood Quality of Life Renal Dialysis* Treatment Outcome Tryptophan / blood* Uremia / blood, psychology, therapy* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 343-65-7/Kynurenine; 670-65-5/Neopterin; 73-22-3/Tryptophan; EC 1.13.11.42/Indoleamine-Pyrrole 2,3,-Dioxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Exocrine pancreatic function in patients with end-stage renal disease.
Next Document: Atypical electrolyte kinetics during an emergency dialysis session in a patient with Leriche syndrom...