| Enhanced cytokines delivery and intercellular adhesion molecule 1 (ICAM-1) expression in glioma by intracarotid infusion of bradykinin analog, RMP-7. | |
| | |
MedLine Citation:
|
PMID: 9329027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of intracarotid infusion of the bradykinin analog, RMP-7, on blood-to-tumor and blood-to-brain transport of three cytokines were investigated. Wistar rats with RG2 gliomas were utilized and a unidirectional transfer constant, Ki, was determined using quantitative autoradiography. Interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), and interleukin-2 (IL-2) were labeled with 125Iodine for quantitative transport studies using autoradiography. Radiolabeled cytokines were injected as an intravenous bolus. Intracarotid infusion of RMP-7 (0.1 microgram kg-1 min-1) increased the selective transport to tumors of IFN-gamma by 3.97-fold (p < 0.005), of TNF-alpha by 5.30-fold (p < 0.005), and of IL-2 by 4.34-fold (p < 0.005), compared to intracarotid saline infusion. To determine whether the increased IFN-gamma or TNF-alpha transport to tumors with RMP-7 could enhance expression of intercellular adhesion molecule 1 (ICAM-1) in tumors, ICAM-1 expression in RG2 glioma was evaluated by immunohistochemistry. Both IFN-gamma and TNF-alpha increased ICAM-1 expression of RG2 cells in vitro. In vivo, intracarotid infusion of IFN-gamma combined with RMP-7 significantly enhanced ICAM-1 expression in intracerebral RG2 gliomas compared to infusion of IFN-gamma without RMP-7. Expression of ICAM-1 was not enhanced by TNF-alpha combined with RMP-7. Intracarotid infusion of RMP-7 is a novel method of cytokines delivery to brain tumors. |
| | |
Authors:
|
S Nakano; K Matsukado; K L Black |
Related Documents
:
|
7945967 - Interferon-gamma and a factor derived from trypanosomes cause behavioural changes in th... 15281097 - Temperature-sensitive polymer-conjugated ifn-gamma induces the expression of ido mrna a... 12789237 - Differential regulation of eotaxin expression by ifn-gamma in airway epithelial cells. 9670937 - Murine graft-versus-host disease in an f1-hybrid model using ifn-gamma gene knockout do... 8286737 - Human cytomegalovirus alters interleukin-6 production by endothelial cells. 8518927 - Sensitivity to n-methyl-d-aspartic acid-induced convulsions is genetically associated w... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Neurological research Volume: 19 ISSN: 0161-6412 ISO Abbreviation: Neurol. Res. Publication Date: 1997 Oct |
Date Detail:
|
Created Date: 1997-11-19 Completed Date: 1997-11-19 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 501-8 Citation Subset: IM |
Affiliation:
|
Jonsson Comprehensive Cancer Center, Division of Neurosurgery, UCLA Medical Center 90095, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Transport / drug effects Bradykinin / administration & dosage, analogs & derivatives*, pharmacology Brain Neoplasms / metabolism*, pathology Capillary Permeability Cytokines / pharmacokinetics* Female Glioma / metabolism*, pathology Infusions, Intra-Arterial Intercellular Adhesion Molecule-1 / metabolism* Interferon-gamma / pharmacokinetics Interleukin-2 / pharmacokinetics Iodine Radioisotopes / pharmacokinetics Neoplasm Transplantation Rats Rats, Wistar Tumor Cells, Cultured Tumor Necrosis Factor-alpha / pharmacokinetics |
| Grant Support | |
ID/Acronym/Agency:
|
1PO1NS25554/NS/NINDS NIH HHS; 1RO1NS32103/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cytokines; 0/Interleukin-2; 0/Iodine Radioisotopes; 0/Tumor Necrosis Factor-alpha; 126547-89-5/Intercellular Adhesion Molecule-1; 159768-75-9/RMP 7; 58-82-2/Bradykinin; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Experience with transcranial magnetic stimulation in evaluation of spinal cord injury.
Next Document: Symmetric temporal patterns in cortical spike trains during performance of a short-term memory task.