| Enhanced coronary vascular turgor effect on post-ischemic diastolic function in hypertrophied hearts. | |
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MedLine Citation:
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PMID: 19589788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effect of coronary perfusion pressure on post-ischemic left ventricular (LV) diastolic function in the hypertrophied heart. LV pressure overload was induced in four-week-old rats by abdominal aortic constriction (AC), with controls (C) undergoing sham operations. At six weeks of age, isolated Langendorff-perfused hearts (perfusion pressures: 75 and 110 mmHg in C and AC hearts, respectively) were subjected to hypothermic global ischemia (15 degrees C, 210 min) followed by 65 min of reperfusion (group I: C hearts subjected to aerobic perfusion alone, group II: C hearts subjected to ischemia/reperfusion, group III: AC hearts subjected to aerobic perfusion alone, group IV: AC hearts subjected to ischemia/reperfusion; n=6/group). LV end-diastolic pressure (LVEDP) at a constant balloon volume was assessed under perfusion pressures of 110, 75, and 0 mmHg during aerobic perfusion alone (groups I and III) or post-ischemic perfusion (groups II and IV). The LVEDP differences between perfusion pressures of 75 and 110 mmHg were 6.2+/-3.2, 3.2+/-2.7, 3.2+/-1.5, and 12.8+/-4.2* mmHg in groups I, II, III, and IV, respectively (*P<0.05 vs. group III). Pressure overload-induced hypertrophied hearts exhibit post-ischemic diastolic dysfunction, which may be caused partly by the enhanced coronary vascular turgor effect on myocardial stiffness. |
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Authors:
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Hiroshi Yamamoto; Fumio Yamamoto; Hajime Ichikawa |
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Publication Detail:
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Type: In Vitro; Journal Article Date: 2009-07-09 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 9 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-23 Completed Date: 2009-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 605-8 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Surgery, Akita University School of Medicine, Hondo 1-1-1, Akita, 010-8543 Japan. h-yama@cvs.med.akita-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Cardiomegaly / etiology*, pathology, physiopathology Coronary Circulation* Diastole Elasticity Heart Arrest, Induced Hypertension / complications*, pathology, physiopathology Male Myocardial Contraction* Myocardial Ischemia / complications*, pathology, physiopathology Myocardium / pathology* Perfusion Rats Rats, Wistar Ventricular Dysfunction, Left / etiology*, pathology, physiopathology Ventricular Pressure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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