Document Detail


Enhanced complement consumption in neuromyelitis optica and Behçet's disease patients.
MedLine Citation:
PMID:  21215465     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The complement system is essential in the pathogenesis of inflammatory central nervous system disorders. To investigate the involvement of complement pathways in neuromyelitis optica (NMO), levels of breakdown products for classical (C4d), alternative (FBb) and common (sC5b-9) pathways were measured in the sera of 28 NMO and control patients (30 Behçet's disease (BD), 29 multiple sclerosis (MS)) and 31 healthy controls by ELISA. Classical and/or alternative pathway consumption was enhanced in NMO and BD patients as compared to MS patients and healthy controls. Our results suggest that NBD and NMO differ from MS by the predominance of complement system involvement.
Authors:
Erdem Tüzün; Murat Kürtüncü; Recai Türkoğlu; Sema Içöz; Münevver Pehlivan; Omer Birişik; Mefküre Eraksoy; Gulsen Akman-Demir
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-5
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  -     ISSN:  1872-8421     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Istanbul University, Istanbul Faculty of Medicine, Department of Neurology, Istanbul, Turkey.
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