| Enhanced co-production of S-adenosylmethionine and glutathione by an ATP-oriented amino acid addition strategy. | |
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MedLine Citation:
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PMID: 22244899 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Effects of amino acids on co-production of S-adenosylmethionine (SAM) and glutathione (GSH) with Candida utilis CCTCC M 209298 were investigated. Both methionine and cysteine showed positive effects on improving intracellular SAM and GSH content simultaneously. Batch fermentative co-production of SAM and GSH was conducted in a 5L stirred fermentor, where the co-production of SAM and GSH was enhanced by 71.3% and 71.5% with 6g/L methionine and 6mmol/L cysteine, respectively. Based on these results together with intracellular ATP levels during batch cultivation of C. utilis CCTCC M 209298, a two-stage amino acid addition strategy was developed by adding 6g/L methionine at 0h and 6mmol/L cysteine at 21h. Under this ATP-oriented strategy, SAM and GSH biosynthesis was further promoted, and the co-production of SAM and GSH reached 669.3mg/L, which was increased by 124.6% compared to that without amino acid addition. |
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Authors:
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Yulei Wang; Dahui Wang; Gongyuan Wei; Na Shao |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-30 |
Journal Detail:
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Title: Bioresource technology Volume: - ISSN: 1873-2976 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9889523 Medline TA: Bioresour Technol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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