| Enhanced circulating soluble LR11 in patients with coronary organic stenosis. | |
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MedLine Citation:
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PMID: 20047743 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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LR11, an LDL receptor family member, is expressed in intimal smooth muscle cells. It was found that the soluble form of LR11 (sLR11) is detected in serum, and the circulating sLR11 levels are positively correlated with intima-media thickness of carotid arteries in dyslipidemic subjects. To clarify the significance of serum sLR11, the circulating sLR11 levels in patients with organic coronary stenosis and the contributing risk factors for them were studied. The subjects, 150 patients with symptoms of coronary artery disease, underwent coronary angiographic examination, and were divided into sex- and age-matched two groups; one is organic coronary stenosis group (OCS) and the other is normal coronary group (NC). Serum sLR11 levels were significantly higher in OCS than in NC (4.9+/-2.7 U vs 3.6+/-1.8 U, p<0.05). Multivariate regression analysis showed that circulating sLR11 is independent contributing factor for the OCS, as well as diabetes mellitus and dyslipidemia. Among various coronary risk factors for sLR11 level, HbA1c showed the highest correlation coefficient (p<0.01). These results suggest that the circulating sLR11 might reflect coronary organic stenosis, and that hyperglycemic condition might be promoting factor for expression of LR11 in intimal smooth muscle cells. |
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Authors:
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Mao Takahashi; Hideaki Bujo; Meizi Jiang; Hirofumi Noike; Yasushi Saito; Kohji Shirai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-16 |
Journal Detail:
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Title: Atherosclerosis Volume: 210 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 581-4 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Cardiovascular Center, Sakura Hospital, Medical Center, Toho University, Chiba, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Angiography / methods Coronary Artery Disease / blood Coronary Stenosis / blood* Female Humans Hyperglycemia / pathology Insulin Resistance LDL-Receptor Related Proteins / blood* Male Membrane Transport Proteins / blood* Middle Aged Models, Biological Myocytes, Smooth Muscle / metabolism Regression Analysis Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/LDL-Receptor Related Proteins; 0/Membrane Transport Proteins; 0/SORL1 protein, human |
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