| Enhanced baroreceptor control of the cardiovascular system by polyunsaturated Fatty acids in heart failure patients. | |
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MedLine Citation:
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PMID: 17045894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The intention of this study was to test the hypothesis that, in heart failure patients, dietary supplementation of polyunsaturated fatty acids (PUFA) enhances arterial baroreceptor control of the cardiovascular system. BACKGROUND: Administration of PUFA reduces the risk of life-threatening arrhythmias in patients surviving myocardial infarction. This might result from potentiation of arterial baroreflexes, but whether or not PUFA enhance baroreflex function has never been studied in humans. METHODS: Patients with post-myocardial infarction left ventricular dysfunction underwent beat-to-beat blood pressure (BP) (Finapres, Ohmeda Inc., Englewood, Colorado) and R-R interval (electrocardiogram) recording; baroreceptor reflexes were assessed from the bradycardic and depressor responses to graded neck suction (NS) as well as by computation of the alpha "spontaneous" baroreflex sensitivity index. Assessments were repeated after prolonged treatment with PUFA (2 g/die, n = 15) or placebo (n = 10). RESULTS: Baseline BP and R-R interval were unaffected by PUFA. Both reflex depressor and bradycardic responses to NS increased after PUFA (respectively from -0.09 +/- 0.01 to -0.16 +/- 0.01 mm Hg x mm Hg(-1), p < 0.01, and from 1.25 +/- 0.9 to 1.76 +/- 1.1 ms x mm Hg(-1), p < 0.04) but not after placebo. The spontaneous baroreflex sensitivity increased in the PUFA (from 8.99 +/- 1.4 to 12.2 +/- 1.2 ms x mm Hg(-1), p < 0.02) but not in the placebo group. Polyunsaturated fatty acids (but not placebo) treatment also significantly increased R-R interval total variance and low-frequency and high-frequency spectral powers. CONCLUSIONS: Dietary PUFA supplementation markedly potentiates baroreflex function and enhances heart rate variability in patients with stable congestive heart failure. |
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Authors:
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Alberto Radaelli; Maria Cazzaniga; Andrea Viola; Giulia Balestri; Maria Bianchi Janetti; Maria G Signorini; Paolo Castiglioni; Arianna Azzellino; Giuseppe Mancia; Alberto U Ferrari |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2006-09-26 |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 48 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-18 Completed Date: 2006-11-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1600-6 Citation Subset: AIM; IM |
Affiliation:
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Divisione di Riabilitazione Cardiologica, Ospedale San Gerardo, Monza, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Baroreflex
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drug effects Blood Pressure / drug effects Cardiovascular System / physiopathology* Dietary Supplements* Fatty Acids, Unsaturated / blood, pharmacology* Female Heart Failure / blood, etiology, physiopathology* Heart Rate / drug effects Humans Male Myocardial Infarction / complications Neck Physical Stimulation Pressoreceptors / drug effects*, physiopathology* Suction |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 2007 Apr 24;49(16):1750; author reply 1750-1
[PMID:
17448379
]
J Am Coll Cardiol. 2006 Oct 17;48(8):1607-9 [PMID: 17045895 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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