Document Detail

Enhanced baroreceptor control of the cardiovascular system by polyunsaturated Fatty acids in heart failure patients.
MedLine Citation:
PMID:  17045894     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The intention of this study was to test the hypothesis that, in heart failure patients, dietary supplementation of polyunsaturated fatty acids (PUFA) enhances arterial baroreceptor control of the cardiovascular system. BACKGROUND: Administration of PUFA reduces the risk of life-threatening arrhythmias in patients surviving myocardial infarction. This might result from potentiation of arterial baroreflexes, but whether or not PUFA enhance baroreflex function has never been studied in humans. METHODS: Patients with post-myocardial infarction left ventricular dysfunction underwent beat-to-beat blood pressure (BP) (Finapres, Ohmeda Inc., Englewood, Colorado) and R-R interval (electrocardiogram) recording; baroreceptor reflexes were assessed from the bradycardic and depressor responses to graded neck suction (NS) as well as by computation of the alpha "spontaneous" baroreflex sensitivity index. Assessments were repeated after prolonged treatment with PUFA (2 g/die, n = 15) or placebo (n = 10). RESULTS: Baseline BP and R-R interval were unaffected by PUFA. Both reflex depressor and bradycardic responses to NS increased after PUFA (respectively from -0.09 +/- 0.01 to -0.16 +/- 0.01 mm Hg x mm Hg(-1), p < 0.01, and from 1.25 +/- 0.9 to 1.76 +/- 1.1 ms x mm Hg(-1), p < 0.04) but not after placebo. The spontaneous baroreflex sensitivity increased in the PUFA (from 8.99 +/- 1.4 to 12.2 +/- 1.2 ms x mm Hg(-1), p < 0.02) but not in the placebo group. Polyunsaturated fatty acids (but not placebo) treatment also significantly increased R-R interval total variance and low-frequency and high-frequency spectral powers. CONCLUSIONS: Dietary PUFA supplementation markedly potentiates baroreflex function and enhances heart rate variability in patients with stable congestive heart failure.
Alberto Radaelli; Maria Cazzaniga; Andrea Viola; Giulia Balestri; Maria Bianchi Janetti; Maria G Signorini; Paolo Castiglioni; Arianna Azzellino; Giuseppe Mancia; Alberto U Ferrari
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-09-26
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  48     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-18     Completed Date:  2006-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1600-6     Citation Subset:  AIM; IM    
Divisione di Riabilitazione Cardiologica, Ospedale San Gerardo, Monza, Italy.
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MeSH Terms
Baroreflex / drug effects
Blood Pressure / drug effects
Cardiovascular System / physiopathology*
Dietary Supplements*
Fatty Acids, Unsaturated / blood,  pharmacology*
Heart Failure / blood,  etiology,  physiopathology*
Heart Rate / drug effects
Myocardial Infarction / complications
Physical Stimulation
Pressoreceptors / drug effects*,  physiopathology*
Reg. No./Substance:
0/Fatty Acids, Unsaturated
Comment In:
J Am Coll Cardiol. 2007 Apr 24;49(16):1750; author reply 1750-1   [PMID:  17448379 ]
J Am Coll Cardiol. 2006 Oct 17;48(8):1607-9   [PMID:  17045895 ]

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