Document Detail

Enhanced adverse electrophysiologic effects of histamine after myocardial infarction in guinea pigs.
MedLine Citation:
PMID:  3155796     Owner:  NLM     Status:  MEDLINE    
To evaluate the electrophysiological sensitivity of infarcted myocardium to histamine, we used microelectrodes to study its effects in isolated guinea-pig left ventricles 1 hr (acute), 24 hr (subacute) and 4 to 6 weeks (chronic) after multiple (6-8) ligations of the left coronary artery system. In both control and infarcted preparations, histamine (10(-8) to 10(-5) M) caused marked concentration-dependent increases in automaticity. Histamine also induced rhythm disturbances, including premature depolarizations, irregular patterns of spontaneous depolarization and spontaneous bursts of rapid ventricular activity. In each case, threshold concentrations for these effects were lowest in the preparations with infarcts. Cimetidine (10(-5) M) abolished the arrhythmogenic effects of histamine, whereas chlorpheniramine (10(-5) M) did not; beta adrenergic blockade induced by propranolol also had no effect. The effects of histamine were mimicked in normal hearts by the H2-agonist dimaprit. These data indicate that threshold concentrations of histamine induce rhythm disturbances in the setting of experimental myocardial infarction. We suggest histamine plays some role in arrhythmias associated with myocardial infarction in humans.
J S Cameron; M S Gaide; P L Goad; C B Altman; J Cuevas; R J Myerburg; A L Bassett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  232     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-03-21     Completed Date:  1985-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  480-4     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Arrhythmias, Cardiac / chemically induced
Chlorpheniramine / pharmacology
Guinea Pigs
Heart / drug effects*
Heart Rate / drug effects
Histamine / physiology*
Myocardial Infarction / physiopathology*
Thiourea / pharmacology
Grant Support
Reg. No./Substance:
132-22-9/Chlorpheniramine; 51-45-6/Histamine; 62-56-6/Thiourea; 65119-89-3/Dimaprit

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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