Document Detail


Enhanced adolescent learning and hippocampal axonal projections following preadolescent spatial exposure to a water or dry maze.
MedLine Citation:
PMID:  22967943     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The present work sought to determine whether preadolescent exposure to a different task in the same spatial environment would lead to enhancement of water-maze performance and changes in hippocampal connectivity. Separate groups of preadolescent (p16-p26) Long Evans rats (LER) were exposed to the same room and arena using either a water-maze (WM) or a dry-maze (DM), while a third group received no exposure to the spatial cues (NT) but were handled. Three weeks later, rats were tested on the WM or DM task in the same room where preadolescent exposure took place. This set up conditions where the DM/WM and WM/DM groups were exposed to the same spatial cues during the preadolescent and adolescent (p40-p44) phases but performed different tests allowing for the dissociation of spatial cue exposure and task familiarity on adolescent performance. When animals experienced similar preadolescent and adolescent conditions (WM/WM or DM/DM), there was improved performance over animals with no preadolescent spatial exposure (NT/WM or NT/DM). In group DM/WM, there was enhanced adolescent performance compared to group NT/WM. In contrast, group WM/DM did not show enhanced adolescent performance. Compared to groups with no preadolescent spatial exposure, groups with both preadolescent and adolescent spatial exposure showed elevated synaptophysin staining in the hippocampal CA3 region indicating an expanded axonal projection in this region. These data suggest the possibility that exposure to spatial cues during the preadolescent period, independent from task-specific requirements, contributes to enhanced adolescent spatial performance on the WM. This appears to be linked with the reorganization of axonal inputs to the CA3 region.
Authors:
Brianne C Wartman; Nicole J Gervais; Catherine Smith; Rachel Comba; Dave G Mumby; Matthew R Holahan
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Publication Detail:
Type:  Journal Article     Date:  2012-08-13
Journal Detail:
Title:  Brain research     Volume:  1475     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  37-48     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Department of Neuroscience, Carleton University, 337 Life Sciences Research Building, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6.
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