Document Detail

Enhanced adenosine A(2B) mediated coronary response in reserpinised rat heart.
MedLine Citation:
PMID:  12644899     Owner:  NLM     Status:  MEDLINE    
In this study, we investigated the effect of noradrenaline depletion on contractile recovery in rat isolated heart following myocardial ischaemia. Groups tested included control tissues and hearts from reserpinised rats. Reserpine 1 mg/kg s.c. was injected into rats 18 to 24 h prior to experiments. Hearts underwent 15 min global normothermic ischaemia followed by 30 min reperfusion. Functional data (end diastolic pressure (EDP), heart rate (HR), left ventricular developed pressure (LVDP), dP/dt(max), dP/dt(min)) showed that contractile function following ischaemia-reperfusion is unaffected by reserpinisation. However, pre- and post-ischaemic coronary flow rates (CFR) were increased by 16 to 38% in hearts from reserpinised rats versus control hearts. Pre-ischaemic CFRs in control hearts (11.17+/-0.67 ml/in(-1) x g tissue(-1), n=9) were significantly lower then CFRs derived from reserpinised rat hearts (14.57+/-0.72 ml/min(-1)/g tissue(-1), n=10). Post-ischaemic reactive hyperaemia was evident in all groups. CFRs in reserpinised hearts remained elevated when compared to pre-ischaemic values through reperfusion (P<0.05). Reserpine treatment did not significantly alter pre- or post-ischaemic adenosine efflux. The A(2B) adenosine receptor antagonist alloxazine (10 microM) attenuated pre- and post-ischaemic CFRs in both control and reserpinised hearts (P<0.05) without altering the hyperaemic response while the A(2A) adenosine receptor antagonist 8-(3-chlorostyryl) caffeine (1 microM) did not alter CFRs in both groups. The A(3) adenosine receptor antagonist MRS1191 (0.1 microM) increased CFR in control and reserpinised hearts (P<0.05). Catecholamine depletion with reserpinisation enhances the responsiveness of the coronary resistance vessels to endogenous adenosine through activation of the A(2B) adenosine receptor.
Roselyn B Rose'Meyer; Glenn J Harrison; John P Headrick
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Publication Detail:
Type:  In Vitro; Journal Article     Date:  2003-02-14
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  367     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-19     Completed Date:  2004-02-24     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  266-73     Citation Subset:  IM    
Heart Foundation Research Centre, School of Health Sciences, Griffith University, PMB50 Gold Coast Mail Centre, 9726, Queensland, Australia.
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MeSH Terms
Adenosine / analogs & derivatives*,  metabolism,  pharmacology
Adrenergic Uptake Inhibitors / pharmacology*
Flavins / pharmacology
Myocardial Contraction / drug effects
Myocardial Ischemia / metabolism,  physiopathology*
Myocardium / metabolism*
Norepinephrine / metabolism
Purines / metabolism
Rats, Wistar
Receptor, Adenosine A2B / antagonists & inhibitors*
Reserpine / pharmacology*
Time Factors
Tyramine / metabolism
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 0/Flavins; 0/Purines; 0/Receptor, Adenosine A2B; 0/Vasodilator Agents; 120-73-0/purine; 20125-40-0/N-(1-methyl-2-phenylethyl)adenosine; 490-59-5/isoalloxazine; 50-55-5/Reserpine; 51-41-2/Norepinephrine; 51-67-2/Tyramine; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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