Document Detail


Enhanced adenosine A(2B) mediated coronary response in reserpinised rat heart.
MedLine Citation:
PMID:  12644899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we investigated the effect of noradrenaline depletion on contractile recovery in rat isolated heart following myocardial ischaemia. Groups tested included control tissues and hearts from reserpinised rats. Reserpine 1 mg/kg s.c. was injected into rats 18 to 24 h prior to experiments. Hearts underwent 15 min global normothermic ischaemia followed by 30 min reperfusion. Functional data (end diastolic pressure (EDP), heart rate (HR), left ventricular developed pressure (LVDP), dP/dt(max), dP/dt(min)) showed that contractile function following ischaemia-reperfusion is unaffected by reserpinisation. However, pre- and post-ischaemic coronary flow rates (CFR) were increased by 16 to 38% in hearts from reserpinised rats versus control hearts. Pre-ischaemic CFRs in control hearts (11.17+/-0.67 ml/in(-1) x g tissue(-1), n=9) were significantly lower then CFRs derived from reserpinised rat hearts (14.57+/-0.72 ml/min(-1)/g tissue(-1), n=10). Post-ischaemic reactive hyperaemia was evident in all groups. CFRs in reserpinised hearts remained elevated when compared to pre-ischaemic values through reperfusion (P<0.05). Reserpine treatment did not significantly alter pre- or post-ischaemic adenosine efflux. The A(2B) adenosine receptor antagonist alloxazine (10 microM) attenuated pre- and post-ischaemic CFRs in both control and reserpinised hearts (P<0.05) without altering the hyperaemic response while the A(2A) adenosine receptor antagonist 8-(3-chlorostyryl) caffeine (1 microM) did not alter CFRs in both groups. The A(3) adenosine receptor antagonist MRS1191 (0.1 microM) increased CFR in control and reserpinised hearts (P<0.05). Catecholamine depletion with reserpinisation enhances the responsiveness of the coronary resistance vessels to endogenous adenosine through activation of the A(2B) adenosine receptor.
Authors:
Roselyn B Rose'Meyer; Glenn J Harrison; John P Headrick
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Publication Detail:
Type:  In Vitro; Journal Article     Date:  2003-02-14
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  367     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-19     Completed Date:  2004-02-24     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  266-73     Citation Subset:  IM    
Affiliation:
Heart Foundation Research Centre, School of Health Sciences, Griffith University, PMB50 Gold Coast Mail Centre, 9726, Queensland, Australia. r.rosemeyer@mailbox.gu.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adenosine / analogs & derivatives*,  metabolism,  pharmacology
Adrenergic Uptake Inhibitors / pharmacology*
Animals
Flavins / pharmacology
Male
Myocardial Contraction / drug effects
Myocardial Ischemia / metabolism,  physiopathology*
Myocardium / metabolism*
Norepinephrine / metabolism
Purines / metabolism
Rats
Rats, Wistar
Receptor, Adenosine A2B / antagonists & inhibitors*
Reperfusion
Reserpine / pharmacology*
Time Factors
Tyramine / metabolism
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 0/Flavins; 0/Purines; 0/Receptor, Adenosine A2B; 0/Vasodilator Agents; 120-73-0/purine; 20125-40-0/N-(1-methyl-2-phenylethyl)adenosine; 490-59-5/isoalloxazine; 50-55-5/Reserpine; 51-41-2/Norepinephrine; 51-67-2/Tyramine; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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